Results 121 to 130 of about 423,721 (164)

Phytogrowth-Inhibitory Compounds from Malmea depressa

Journal of Natural Products, 1996
Fractionation of the CHCl3 extract of the stem bark of Malmea depressa, guided by phytogrowth-inhibitory bioassays, led to the isolation of four known phenylpropanoids:  1,2,3,4-tetramethoxy-5-(2-p...
A, Jimenez Arellanes, R, Mata, B, Lotina-Henssen, A L, Anaya Lang, L, Velasco Ibarra   +4 more
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Tyrosinase Inhibitory Activity of the Olive Oil Flavor Compounds

Journal of Agricultural and Food Chemistry, 1999
A series of alpha,beta-unsaturated aldehydes, otherwise known as (2E)-alkenals, characterized from the olive Olea europaea L. (Oleaceae) oil flavor was found to inhibit the oxidation of L-3, 4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase, and the inhibition kinetics analyzed by a Lineweaver-Burk plot found that they are ...
I, Kubo, I, Kinst-Hori
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Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds

Journal of Medicinal Chemistry, 1983
Ten eicosanoid compounds (3, 6, 9, 11, 12, 15, 18, 21, 23, and 25), methyl (6E,8Z,11Z,14Z)-5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE, 10), leukotriene A4 (26), and (5S,6E,8E,10E,12RS,14E)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid (5,12-diHETE, 27) were prepared and their inhibitory activities against the 5-lipoxygenase from guinea pig ...
Y, Arai, K, Shimoji, M, Konno, Y, Konishi, S, Okuyama, S, Iguchi, M, Hayashi, T, Miyamoto, M, Toda   +8 more
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Aldose Reductase Inhibitory Compounds from Xanthium strumarium

Archives of Pharmacal Research, 2013
As part of our ongoing search for natural sources of therapeutic and preventive agents for diabetic complications, we evaluated the inhibitory effects of components of the fruit of Xanthium strumarium (X. strumarium) on aldose reductase (AR) and galactitol formation in rat lenses with high levels of glucose.
Ha Na, Yoon, Min Young, Lee, Jin-Kyu, Kim, Hong-Won, Suh, Soon Sung, Lim   +4 more
openaire   +2 more sources

Antimicrobial Browning-Inhibitory Effect of Flavor Compounds in Seaweeds

Journal of Applied Phycology, 2006
Since ancient times, the antimicrobial properties of seaweeds have been recognized. However, antimicrobial activities of volatile compounds in seaweeds have not been explored so far. Here, essential oils from seaweeds including green, brown and red algae such as Laminaria japonica, Kjellmaniella crassifolia, Gracilaria verrucosa and Ulva pertusa were ...
Tadahiko Kajiwara, Kenji Matsui, Yoshihiko Akakabe, Takushi Murakawa, Chikako Arai   +4 more
openaire   +1 more source

AUTOTAXIN INHIBITORY COMPOUNDS

2016
The present invention relates to compounds of formula I, wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions ...
Stockley, Martin, Lee, MacDonald, Ellen, Catherine, Pritom,, Shah, Jordan,, Allan, Hitchin,, James, Hamilton,, Niall   +5 more
openaire   +1 more source

Antihypertensive compounds with potent protein kinases inhibitory activity

Life Sciences, 1989
A new indorocarbazole antibiotic SF2370 has been found in the culture broth of Actinomadura sp.; it has also been found to have the activities of antihypertension and diuresis. Derivatives of SF2370, NA0344, NA0345 and NA0346, when injected (0.1-1 mg/kg i.v.) significantly lowered the blood pressure of anesthetized normotensive rats and showed a long ...
M, Hachisu, T, Hiranuma, M, Koyama, M, Sezaki   +3 more
openaire   +2 more sources

PARG INHIBITORY COMPOUNDS

2016
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions
Jordan, Allan, Waszkowycz,, Bohdan, Hutton, Colin, Waddell, Ian, Hitchin, James, Smith, Kate, Hamilton, Niall, Mcgonagle, Alison   +7 more
openaire   +1 more source

Natural compounds with xanthine oxidase inhibitory activity: A review

Chemical Biology & Drug Design, 2019
AbstractHyperuricemia (HUA), a disease due to an elevation of body uric acid level and responsible for various diseases such as gout, cardiovascular disorders, and renal failure, is a major ground debate for the medical science these days. Considering the risk factors linked with allopathic drugs for the treatment of this disease, the debate has now ...
Arshad Mehmood, Muhammad Ishaq, Lei Zhao, Bushra Safdar, Ashfaq‐ur Rehman, Masooma Munir, Ali Raza, Muhammad Nadeem, Waheed Iqbal, Chengtao Wang   +9 more
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Tibolone: a compound with tissue specific inhibitory effects on sulfatase

Molecular and Cellular Endocrinology, 2001
The aim was to test whether sulfatase activity is differently regulated by tibolone in human bone, endometrium and breast cells since selective inhibition of sulfatases in various tissues may contribute to the tissue-specificity of tibolone. Tibolone, its 3 alpha- and 3 beta-hydroxy metabolites and their 3-sulfated forms, and its Delta(4)-isomer ...
M E, de Gooyer, G T, Kleyn, K C, Smits, A G, Ederveen, H A, Verheul, H J, Kloosterboer   +5 more
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