Results 101 to 110 of about 2,365,869 (296)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Synthesis of curcumin derivatives for suppression of castration-resistant prostate cancer

Journal of Chemical Research
In this work, 20 curcumin derivatives containing halogen atoms or nitrogen atoms were synthesized for suppression of castration-resistant prostate cancer.
Shunze Gong, Chixiang Yuan, Hang Hu, Defeng Xu   +3 more
doaj   +1 more source

Screening of MMV pandemic response and pathogen box compounds against pan-drug-resistant Klebsiella pneumoniae to identify potent inhibitory compounds. [PDF]

New Microbes New Infect, 2023
Sivasankar S, Premnath MA, Boppe A, Grobusch MP, Jeyaraj S.   +4 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

In silico analysis of angiotensin-converting enzyme inhibitory compounds obtained from soybean [Glycine max (L.) Merr.]. [PDF]

Front Physiol, 2023
Ramlal A, Bhat I, Nautiyal A, Baweja P, Mehta S, Kumar V, Kumar V, Tripathi S, Mahto RK, Saini M, Mallikarjuna BP, Saluja S, Lal SK, Subramaniam S, Fawzy IM, Rajendran A.   +15 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Inhibitory effects of the main compounds of oregano essential oil against some pathogenic fungi

, 2008
The in vitro activity of essential oil compounds of Origanum heracleoticum L. was tested against Verticillium dahliae, Fusarium oxysporum, Phoma tracheiphila, Phytophthora cactorum and Botrytis cinerea by the well diffusion method using four different ...
SACCO, Ignazia, SALAMONE, A, CABRAS, P, SCARITO, Giuseppa, ANGIONI, A.   +4 more
core  

Minimum inhibitory concentration (MIC) of compounds against six fungal strains.

, 2018
Minimum inhibitory concentration (MIC) of compounds against six fungal strains.
Mukesh Kumari (5122631), Indresh K. Maurya (5122625), Ramesh Kataria (5122628), Sunil Kumar (102321), Vinod Kumar (48743), Vikram Saini (34826), Jayant Sindhu (634210)   +6 more
core   +1 more source

Characterization of Antioxidant and α-Glucosidase Inhibitory Compounds of Cratoxylum formosum ssp. pruniflorum and Optimization of Extraction Condition. [PDF]

Antioxidants (Basel), 2023
An H, Thanh LN, Khanh LQ, Ryu SH, Lee S, Yeon SW, Lee HH, Turk A, Lee KY, Hwang BY, Lee MK.   +10 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source