Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Structures and LSD1 inhibitory activities of compounds 1–35.
, 2017 Structures and LSD1 inhibitory activities of compounds 1–35.
Liping Wei (10166) +6 more
core +1 more source
Synthesis and in vitro activity tests of N-benzoyl-N'-phenylthiourea derivatives as macrophage migration inhibitory factor [Síntesis y pruebas de actividad in vitro de derivados de N-benzoil-N'-feniltiourea como factor inhibidor de la migración de macrófagos] [PDF]
, 2023 Context: The COVID-19 pandemic in 2020 resulted in widespread mortalities due to cytokine storms in the affected patients. Macrophage migration inhibitory factor (MIF) is one of the most interesting targets in developing anti-COVID-19 drugs.
Suhud, Farida +7 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design, synthesis, and α-glucosidase inhibitory activity study of indole-urea derivatives
Guangxi Yike Daxue xuebaoObjective To design and synthesize novel non-sugar-based α-glucosidase inhibitors by a simple synthesis method and evaluate their inhibitory activity.
Ruiqi HUANG, Yingli DENG, Gaojie YE
doaj +1 more source
Molecules, 2016 This study was aimed at examining the variations in the metabolite constituents of the different Ajwa grades and farm origins. It is also targeted at establishing the correlations between the metabolite contents and the grades and further to the nitric ...
Nur Ashikin Abdul-Hamid +6 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Cancer Chemopreventive Activity of Xanthones from
Natural Product Communications, 2018 In our continuing search for compounds with antitumor-promoting activity, we screened eight xanthones isolated from Calophyllum elatum Bedd. (Guttiferae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA ...
Chihiro Ito +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18.
, 2019 Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18.
M. Iqbal Choudhary (598049) +3 more
core +1 more source