Results 91 to 100 of about 2,365,869 (296)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

, 2012
Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels.
Aaisha Opel, Aaisha eOpel, Richard Ang, Richard eAng, Opel, A, Tinker, A, Andrew Tinker, Ang, R, Andrew eTinker   +8 more
core   +1 more source

In-silico studies of inhibitory compounds against protease enzymes of SARS-CoV-2. [PDF]

Medicine (Baltimore), 2023
Khan S, Nasrullah, Hussain A, Asif M, Sattar FA, Audhal FA, Qadir MI, Hamdard MH.   +7 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Ascorbic acid potentiates the Giardia duodenalis growth inhibitory activity of pure Terminalia ferdinandiana Exell compounds

, 2020
Giardiasis, one of the most common causes of diarrhoeal disease, is caused by gastrointestinal protozoal parasites of the genus Giardia. Metronidazole is the most commonly used drug to treat giardiasis.
Rayan, P, Cock, IE
core   +1 more source

Sponge-associated fungi and their bioactive compounds - the Suberites case [PDF]

, 2008
Specimens of Suberites domuncula that had been cultured in aquaria for 4 weeks were analyzed for their associated fungi. A total of 81 fungal strains belonging to 20 different genera was isolated and identified by morphological and molecular methods. The
Edrada-Ebel, R.A., Mueller, Werner E. G., Ebel, R., Zuccaro, Alga, Proksch, P., Diesel, A., Ebel, Rainer, Schulz, Barbara, Bayer, Mirko, Grebenyuk, V., Riebe, Frank, Liu, H., Draeger, Siegfried, Li, Xiang, Müller, W.E.G., Liu, Hongbing, Bayer, M., Edrada, R., Proksch, Peter, Lin, Wen Han, Li, X., Edrada, RuAngelie, Han Lin, W., Diesel, Arnulf, Grebenyuk, Vladislav, Riebe, F., Schulz, B., Zuccaro, A., Draeger, S.   +28 more
core   +1 more source

Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126. [PDF]

Mar Drugs, 2023
Hao YJ, Zou ZB, Xie MM, Zhang Y, Xu L, Yu HY, Ma HB, Yang XW.   +7 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Inhibitory properties of DENV polymerase N-pocket compounds.

, 2016
Inhibitory properties of DENV polymerase N-pocket compounds.
Ujjini Manjunatha (203605), Christian Guy Noble (2922246), Julien Lescar (50521), Rishi Arora (401751), Fumiaki Yokokawa (1780501), Abbas El Sahili (641877), Xuping Xie (2922237), Cheah Chen Seh (2922243), Siew Pheng Lim (241646), Shahul Nilar (1639123), Grace Kar Yarn Chan (2922240), Timothy Benson (2922234), Kah Fei Wan (1639141), Hongping Dong (327340), Tingjin Sherryl Soh (702992), Pei-Yong Shi (241650)   +15 more
core   +1 more source

Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources. [PDF]

Front Pharmacol, 2022
Tan Y, Liu M, Li M, Chen Y, Ren M.
europepmc   +1 more source