Results 71 to 80 of about 299,758 (277)

Learning-induced enhancement of feedback inhibitory synaptic transmission [PDF]

Learning & Memory, 2009
Olfactory-discrimination learning results with a series of intrinsic and excitatory synaptic modifications in piriform cortex pyramidal neurons. Here we show that such learning results with long-lasting enhancement of inhibitory synaptic transmission onto proximal dendrites of these pyramidal neurons.
Inbar, Brosh, Edi, Barkai
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia.

PLoS ONE, 2012
Schizophrenia encompasses a wide variety of cognitive dysfunctions, a number of which can be understood as deficits of inhibition. To date, no research has examined 'conditioned inhibition' in schizophrenia--the ability of a stimulus that signals the ...
Zhimin He, Helen J Cassaday, S Bert G Park, Charlotte Bonardi   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

AI-Driven Rapid Screening and Characterization of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Goat Blood Proteins: An Integrative In Silico and Experimental Strategy

Foods
To enhance the screening efficiency of bioactive peptides, an AI-driven approach was employed to screen DPP-IV inhibitory peptides from goat blood proteins by an integrated in silico, in vitro, and machine learning strategy.
Jingjie Tan, Sirong Huang, Dongjing Wu, Zhongquan Zhao, Yongju Zhao, Yu Fu, Wei Wu   +6 more
doaj   +1 more source

Determintion of the acute and persistant effects of Aluminium on memory and learning Abilities of rat [PDF]

Journal of Kerman University of Medical Sciences, 2001
In regard to the role of Aluminium in the emergence of psychological disorded in patients with chronic kidney diseases,this research project studied the acute,and chronic effects of Alluminium on different stages of memory and learning abilitis,after ...
H. Alaei, A.A Moshtaghi, KH Rezaei
doaj  

CA1-projecting subiculum neurons facilitate object-place learning. [PDF]

, 2019
Recent anatomical evidence suggests a functionally significant back-projection pathway from the subiculum to the CA1. Here we show that the afferent circuitry of CA1-projecting subicular neurons is biased by inputs from CA1 inhibitory neurons and the ...
Chen, Lujia, Golshani, Peyman, Holmes, Todd C, Jiang, Li, Jin, Suoqin, Johnston, Kevin G, Lin, Xiaoxiao, Nie, Qing, Nitz, Douglas A, Qiao, Xin, Sun, Yanjun, Xu, Xiangmin, Zhou, Pengcheng   +12 more
core   +1 more source

State-Dependent Computation Using Coupled Recurrent Networks [PDF]

, 2008
Although conditional branching between possible behavioral states is a hallmark of intelligent behavior, very little is known about the neuronal mechanisms that support this processing. In a step toward solving this problem, we demonstrate by theoretical
Bongard J., Dayan P., Hopcroft J., Maass W., McCulloch W., Minksy L., Neftci E., Rodger S., Rodney J. Douglas, Seung H. S., Strogatz S., Ueli Rutishauser, von Neumann J.   +12 more
core   +5 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Time and Inhibitory Learning

, 2011
Associative theories of learning state that an organism acquires new behaviors when associations are formed between a Conditioned Stimulus (CS) and an Unconditioned Stimulus (US). Alternative theories suggest that learning is not reliant on associations between stimuli, but rather on the temporal information conveyed by stimuli. Studies have shown that
openaire   +2 more sources