Results 51 to 60 of about 7,910,042 (288)

Learning-induced enhancement of feedback inhibitory synaptic transmission [PDF]

Learning & Memory, 2009
Olfactory-discrimination learning results with a series of intrinsic and excitatory synaptic modifications in piriform cortex pyramidal neurons. Here we show that such learning results with long-lasting enhancement of inhibitory synaptic transmission onto proximal dendrites of these pyramidal neurons.
Inbar, Brosh, Edi, Barkai
openaire   +2 more sources

The role of 24-h movement Behaviors in preschool children’s learning ability: the mediating effect of inhibitory control

Frontiers in Psychology
PurposeTo investigate the impact of 24-h movement behaviors—sleep (SP), sedentary behavior (SB), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA)—on preschool children’s learning ability, with emphasis on inhibitory ...
Chang Zhenya, Huang Jia
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimal percentage of inhibitory synapses in multi-task learning [PDF]

Scientific Reports, 2015
AbstractPerforming more tasks in parallel is a typical feature of complex brains. These are characterized by the coexistence of excitatory and inhibitory synapses, whose percentage in mammals is measured to have a typical value of 20-30%. Here we investigate parallel learning of more Boolean rules in neuronal networks.
Capano V, Herrmann HJ, DE ARCANGELIS, Lucilla   +2 more
openaire   +5 more sources

Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning

eLife, 2018
Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially through the integration of adult-born inhibitory interneurons resulting
Nathalie Mandairon, Nicola Kuczewski, Florence Kermen, Jérémy Forest, Maellie Midroit, Marion Richard, Marc Thevenet, Joelle Sacquet, Christiane Linster, Anne Didier   +9 more
doaj   +1 more source

The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling

Scientific Reports, 2023
Glyphosate, a herbicide marketed as Roundup, is widely used but there are concerns this exposure could impair cognitive function. In the CA1 region of rat hippocampal slices, we investigated whether glyphosate alters synaptic transmission and long-term ...
Yukitoshi Izumi, Kazuko A. O’Dell, Charles F. Zorumski   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Optogenetic manipulation of inhibitory interneurons can be used to validate a model of spatiotemporal sequence learning

Frontiers in Computational Neuroscience, 2023
The brain uses temporal information to link discrete events into memory structures supporting recognition, prediction, and a wide variety of complex behaviors.
Jackson Rozells, Jeffrey P. Gavornik
doaj   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source