Results 41 to 50 of about 7,910,042 (288)

Backward conditioning reveals flexibility in infralimbic cortex inhibitory memories

eLife
While the infralimbic cortex (IL) is recognized as critical for behavioral inhibition, the content of the inhibitory memories stored in this region remains elusive.
Nura W Lingawi, Billy Chieng, R Fred Westbrook, Nathan Holmes, Mark E Bouton, Vincent Laurent   +5 more
doaj   +1 more source

Infantile Amnesia can be Operationalized as a Psychological Meta Norm in the Development of Memory

Journal of Integrative Neuroscience
This paper offers a syncretic synthesis of the highlights of the scientific knowledge accumulated to date on the mechanisms of infantile amnesia (IA). IA can be conceptualized as a meta-norm of memory development.
Bozhidara Stoencheva, Kristina Stoyanova, Drozdstoy Stoyanov   +2 more
doaj   +1 more source

Risk-Sensitive Inhibitory Control for Safe Reinforcement Learning

2023 62nd IEEE Conference on Decision and Control (CDC), 2023
The 62nd IEEE Conference on Decision and Control, Dec.
Lederer, Armin, Noorani, Erfaun, Baras, John S., Hirche, Sandra   +3 more
openaire   +4 more sources

Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.

PLoS ONE, 2013
Associative fear learning, resulting from whisker stimulation paired with application of a mild electric shock to the tail in a classical conditioning paradigm, changes the motor behavior of mice and modifies the cortical functional representation of ...
Malgorzata Jasinska, Ewa Siucinska, Ewa Jasek, Jan A Litwin, Elzbieta Pyza, Malgorzata Kossut   +5 more
doaj   +1 more source

An examination of the effects of stimulant medication on response inhibition: A comparison between children with and without attention deficit hyperactivity disorder [PDF]

, 2011
This study investigated whether methylphenidate is effective in improving response inhibition in children with Attention Deficit Hyperactivity Disorder (ADHD).
Rachel Brackenridge, Brackenridge, Rachel, April Quigley, Karen McKenzie, George C. Murray, Quigley, April, McKenzie, Karen, Murray, George   +7 more
core   +1 more source

Heritability and correlations among learning and inhibitory control traits [PDF]

Behavioral Ecology, 2020
AbstractTo understand the evolution of cognitive abilities, we need to understand both how selection acts upon them and their genetic (co)variance structure. Recent work suggests that there are fitness consequences for free-living individuals with particular cognitive abilities.
Joah R Madden, Alastair J Wilson, Mark A Whiteside, Jayden O van Horik, Philippa R Laker, Deborah A Dawson, Christine E Beardsworth, Gracie Adams, Ellis J G Langley   +8 more
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Maximizing expectancy violation and exposure outcomes in patients with PTSD

European Journal of Psychotraumatology
Background: It has been proposed that maximizing expectancy violation enhances the efficacy of exposure therapy. The clinical utility of expectancy violation remains unclear and it has not yet been studied in PTSD.Objective: We aimed to test whether ...
Marike J. Kooistra, Maartje Schoorl, Danielle A. C. Oprel, Willem van der Does, Rianne A. de Kleine   +4 more
doaj   +1 more source

Enriched expression of NF1 in inhibitory neurons in both mouse and human brain

Molecular Brain, 2019
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by loss-of-function mutations in NF1 gene, which encodes a GTPase activating protein for RAS.
Hyun-Hee Ryu, Minkyung Kang, Jinsil Park, Sung-Hye Park, Yong-Seok Lee   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source