Results 141 to 150 of about 108,180 (299)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

The neuropharmacology of baclofen [PDF]

, 1988
AI Shapovalov, B Ault, B Ault, B Ault, B Ault, B Ault, B Sutor, B Sutor, BH Gähwiler, BH Gähwiler, BW Connors, CF Terrence, CG Swahn, CN Scholfield, CR Cain, D Stevens, DR Curtis, DR Curtis, DR Curtis, DR Gehlert, DR Hill, E Cherubini, E Knutsson, E Mugnaini, E Roberts, E Schlicker, EW Karbon, FK Pierau, FK Pierau, GAR Johnston, GE Fagg, GGS Collins, GP Wilkin, GW Price, H Fukuda, H Keberle, H Möhler, H Ono, HJ Bein, HL Haas, HR Olpe, HR Olpe, HR Olpe, J Davies, J Davies, J Davies, J Swaynok, JJ Dreifuss, JL Henry, JL Henry, JL Henry, JR Bianchine, JR Howe, JW Phillis, K Dunlap, K Koketsu, K Krnjevic, KJ Fotherby, KS Saito, M Desarmenien, M Fillenz, M Inoue, M Inoue, M Kato, MA Simmonds, MR Klee, N Auden, N Ogata, NG Bowery, NG Bowery, NG Bowery, NG Bowery, NR Newberry, NR Newberry, NR Newberry, P Ashby, P Krogsgaard-Larsen, P Polc, PR Wilson, R Benecke, R Capek, RA Davidoff, RD Pinnock, RF Schmidt, RH Evans, RJ Brady, RR Young, RW Birkmayer, S Fox, SJ Enna, SJ Potashner, SJ Potashner, SR Barry, SR Zukin, TH Lanthorn, TJ Blaxter, U Heinemann, U Misgeld, V Ben-Ari, W Haefely, W Haefely, W Laskey, W Laskey, W Zieglgänsberger, WJ Wojcik   +104 more
core   +1 more source

MiR‐30a‐5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β‐catenin pathway

Epilepsia Open, Volume 11, Issue 3, Page 983-1002, June 2026.
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang, Xu Zhang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment

Exploration, EarlyView.
This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yisheng Chen, Zhijie Zhao, Changli Wang, Xiaomin Zhang   +11 more
wiley   +1 more source

SNAP47 Silencing Impairs the Morphology and Neurotransmission of Hippocampal GABAergic Neurons. [PDF]

Mol Neurobiol
He Z, Camacho M, Trimbuch T, Heilmann H, Rosenmund C, Vida I, Münster-Wandowski A.   +6 more
europepmc   +1 more source

Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

Food Chemistry International, EarlyView.
Diabetic encephalopathy (DME) impairs neurobehavior, neurochemicals, oxidative stress, and inflammation. This study evaluated the effects of hesperidin (HSP), exercise (EX), and acarbose (ACA) alone or combined on diabetic rats. Treatments reduced AChE, BChE, ACE, arginase, ATPDase, 5′‐nucleotidase, ADA, LDH, TBARS, and ROS, while increasing IL‐10, SOD,
Idowu Sunday Oyeleye, Olajide Raymond Ojo, Taiwo Olawale Adeleke, Adeyinka Sunday Ajeigbe, Mercy Gladys Tenywa, Oboh Ganiyu   +5 more
wiley   +1 more source

Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic Plasticity. [PDF]

J Neurosci
Lech A, Wiera G, Mozrzymas JW.
europepmc   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source