Results 141 to 150 of about 71,654 (304)

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

The developmental regulation of local and descending control of dorsal horn neurons in the rat [PDF]

, 2010
Neonatal responses to peripheral cutaneous sensory stimuli appear hyperexcitable compared to those of the adult, at both behavioural and cellular levels.
Koch, S.C.
core  

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source

All‐Electric Mimicking of Synaptic Plasticity Based on the Noncollinear Antiferromagnetic Device

Advanced Electronic Materials
Neuromorphic computing, which seeks to replicate the brain's ability to process information, has garnered significant attention due to its potential to achieve brain‐like computing efficiency and human cognitive intelligence.
Cuimei Cao, Wei Duan, Xiaoyu Feng, Yan Xu, Yihan Wang, Zhenzhong Yang, Qingfeng Zhan, Long You   +7 more
doaj   +1 more source

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

Enhanced Inhibitory Neurotransmission as a Therapeutic Target in ApoE4-Related Alzheimer’s Disease [PDF]

, 2017
ApoE4 is the main genetic risk factor for Alzheimer’s disease (AD) and causes dysfunction and death in inhibitory interneurons in humans and AD mouse models.
Nova, Philip W.
core  

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Expanding the electroclinical spectrum of TANC2‐related disorders: Lennox–Gastaut syndrome and related developmental epileptic phenotypes

Epilepsia Open, EarlyView.
Abstract Objective Neurodevelopmental disorders (NDDs) and epilepsy are often associated. Increasing evidence highlights a pivotal role for pathogenic variants in genes encoding synaptic scaffolding proteins. Within this group, TANC2 has recently been implicated in intellectual developmental disorder with autistic features and language delay, with or ...
Lorenzo Perilli, Carlotta Stipa, Gianmichele Villano, Laura Licchetta, Leo Strothmann, Robin Tobias Jauss, Gerhard Josef Kluger, Raffaella Minardi, NETRE consortium, Giuseppe Gobbi, Salvatore Grosso, Francesca Bisulli, Pasquale Striano   +12 more
wiley   +1 more source