Results 191 to 200 of about 71,654 (304)

Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks. [PDF]

Nat Commun
Mazzachi P, McDonald E, Greenberg Z, Puerta AN, Tran J, De Silva MI, Christensen C, Adams R, Loskarn S, Beard H, Zabolocki M, Elmasri M, Maack M, Elvidge KL, Hutchinson MR, O'Neill C, Hemsley KM, Melton L, Smith N, Bardy C.   +19 more
europepmc   +1 more source

Role of Concentration in Opposing Effects of Anandamide on Nociceptive Synapses versus Non-nociceptive Synapses. [PDF]

eNeuro
Burrell BD.
europepmc   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

ZCCHC17: a target for synaptic dysfunction and neuronal excitability in Alzheimer's disease. [PDF]

Front Aging Neurosci
Klub BA, Teich AF, Cortese GP.
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Adenosine A₁ and A_2A Receptors in Sleep Disorders: Mechanisms and Therapeutic Implications. [PDF]

Biomol Ther (Seoul)
Jee HJ, Youn C, Lee H, Jung YS.
europepmc   +1 more source

Fast and slow inhibitory postsynaptic potentials in the piriform cortex neurons.

Proceedings of the Japan Academy, Series B, 1978
MORI, Kensaku, SATOU, Masahiko, TAKAGI, Sadayuki F.   +2 more
openaire   +2 more sources

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Dopamine-Mediated Attenuation of OECT-Based Aqueous Artificial Chemical Synapses. [PDF]

ACS Appl Mater Interfaces
Zhang H, Xu X, He W, Isobe A, Liu Y, Zhao Y, Michinobu T.   +6 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source