β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels
Epilepsia, EarlyView.β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi +8 more
wiley +1 more source
Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation. [PDF]
Int J Mol SciGhiyamihoor F, Asemi Rad A, Marzban H.
europepmc +1 more source
Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition
Epilepsia, EarlyView.Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga +5 more
wiley +1 more source
A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity. [PDF]
PLoS Comput BiolAhokainen I, Linne ML.
europepmc +1 more source
SOME ANALYSES OF THE SLOW INHIBITORY POSTSYNAPTIC POTENTIAL IN BULLFROG SYMPATHETIC GANGLIA
, 1975 Kyozo KOKETSU, Masaki Nakamura
openalex +2 more sources
New insights into epileptic spasm generation and treatment from the TTX animal model
Epilepsia Open, EarlyView.Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source
Altered Excitation-Inhibition Balance and mGluR<sub>1/5</sub>-Driven Plasticity in the Motor Cortical Surface in a Rat Model of Parkinson's Disease. [PDF]
Int J Mol SciShin H +10 more
europepmc +1 more source
Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley +1 more source
GABA<sub>A</sub> Receptor Trafficking Disruption in Epilepsy: From Assembly to Synaptic Dysfunction. [PDF]
SynapseMohammadpour T, Mohammadzadeh R.
europepmc +1 more source