Results 211 to 220 of about 16,069 (248)
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Deconstructing iNKT cell development at single-cell resolution
Trends in Immunology, 2022Invariant natural killer T (iNKT) cells are increasingly regarded as disease biomarkers and immunotherapeutic targets. However, a greater understanding of their biology is necessary to effectively target these cells in the clinic. The discovery of iNKT1/2/17 cell effector subsets was a milestone in our understanding of iNKT cell development and ...
Thierry Mallevaey +2 more
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Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis [PDF]
Cell Metabolism, 2020 Ayano C Kohlgruber +2 more
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iNKT-Cell Responses to Glycolipids
Critical Reviews in Immunology, 2005Invariant natural killer T (iNKT) cells are an unusual group of T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related protein CD1d. Because iNKT cells play a regulatory role in the immune system, they are attractive targets for immunotherapy.
Vrajesh V, Parekh +2 more
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The interaction between iNKT cells and B cells
Journal of Leukocyte Biology, 2021AbstractInvariant natural killer T cells (iNKTs) bridge the innate immunity with the adaptive immunity and their interaction with B cells has been extensively studied. Here, we give a complete overview of these two cells, from their mechanism of interaction to clinical prospects and existing problems.
Tong, Zhu +9 more
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iNKT Cells in Allergic Disease
2007Recent studies indicate that invariant TCR+ CD1d-restricted natural killer T (iNKT) cells play an important role in regulating the development of asthma and allergy. iNKT cells can function to skew adaptive immunity toward Th2 responses, or can act directly as effector cells at mucosal surfaces in diseases such as ulcerative colitis and bronchial ...
E H, Meyer, R H, DeKruyff, D T, Umetsu
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iNKT cells need UTX-tra demethylation
Nature Immunology, 2017The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells.
S Harsha, Krovi, Laurent, Gapin
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Adjuvant activity mediated by iNKT cells
Seminars in Immunology, 2010Invariant natural killer T (iNKT) cells have adjuvant activity due to their ability to produce large amounts of IFN-gamma, which activates other cells in innate and acquired systems, and orchestrates protective immunity. Based on these adjuvant mechanisms, we developed iNKT cell-targeted adjuvant therapy and carried out a phase I/IIa trial on advanced ...
Shinichiro, Fujii +5 more
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Clinical Immunology, 2019
Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and promote anti-tumor and anti-pathogen immunity.
Mohammad, Fereidouni +2 more
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Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and promote anti-tumor and anti-pathogen immunity.
Mohammad, Fereidouni +2 more
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GVHD protection? ThiNK iNKT cells
Blood, 2012In this issue of Blood , Rubio et al report that posttransplant invariant NKT (iNKT) cell recovery is inversely correlated with the risk of developing GVHD after stem cell transplantation ...
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