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Expansion of Human iNKT Cells Ex Vivo
2021Invariant natural killer T (iNKT) cells are credited with antitumor activity by preclinical studies and clinical trials. Efficient expansion of iNKT cells ex vivo is essential for their translational usage. The culturing procedure described here provides an optimized method for ex vivo expansion of iNKT cells using recombinant human IL-15 (rhIL-15) and
Jing, Wang, Chen, Zhao, Jianqing, Xu
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Science Signaling, 2012
Invariant natural killer T cells produce anti-inflammatory cytokines in the adipose tissue and protect against diet-induced obesity.
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Invariant natural killer T cells produce anti-inflammatory cytokines in the adipose tissue and protect against diet-induced obesity.
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Genetic Analysis of iNKT Cell Development and Function
2021Natural killer T (NKT) cells are among the immediate and early responding immune cells and are important players in autoimmune diseases and tumor immunity. This unique subset of T cells shares properties of natural killer cells and T cells. Proper identification and characterization of NKT cell subsets is essential to understand the function and ...
Julie, Sahler +5 more
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2008
The complexity of the immune system requires mechanisms, cellular and molecular, that coordinate early innate immune responses to those of late adaptive immune responses. One type of immune cell that is able to mediate this bridge between innate immunity and adaptive immunity is the invariant natural killer T (iNKT) cell. In recent years, much research
Dalam Ly, Terry L. Delovitch
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The complexity of the immune system requires mechanisms, cellular and molecular, that coordinate early innate immune responses to those of late adaptive immune responses. One type of immune cell that is able to mediate this bridge between innate immunity and adaptive immunity is the invariant natural killer T (iNKT) cell. In recent years, much research
Dalam Ly, Terry L. Delovitch
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Unraveling tumor-specific iNKT cell plasticity
The Journal of Immunology, 2020Abstract Despite the overall success of T-cell based immunotherapies, the number of patients that benefit is still lower than expected. Invariant Natural Killer T cells (iNKTs) offer an alternative and appealing therapeutic platform owing to their intrinsic features and independence from MHC restriction.
Filippo Cortesi +4 more
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SSRN Electronic Journal, 2022
AbstractThe stepwise development of thymic invariant natural killer T (iNKT) cells is controlled by the TCR signal strength. The scaffold protein Kinase D interacting substrate of 220 kDa (Kidins220) binds to the TCR regulating TCR signaling. T cell-specific Kidins220 knock-out (T-KO) mice contain severely decreased iNKT numbers.
Laurenz A. Herr +9 more
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AbstractThe stepwise development of thymic invariant natural killer T (iNKT) cells is controlled by the TCR signal strength. The scaffold protein Kinase D interacting substrate of 220 kDa (Kidins220) binds to the TCR regulating TCR signaling. T cell-specific Kidins220 knock-out (T-KO) mice contain severely decreased iNKT numbers.
Laurenz A. Herr +9 more
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iNKT Cells: Innate Lymphocytes with a Diverse Response
Critical Reviews in Immunology, 2014It is now established that natural killer T (NKT) cells can influence adaptive immune responses by producing vast amounts of cytokines. Different subsets of NKT cells with distinctive functional characteristics regarding cytokine production have been described.
Monteiro, Marta, Graca, Luis
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A nano-engager for iNKT cells in cancer
Nature Cancer, 2020Invariant natural killer T cells (iNKT cells) are innate-like CD1d-restricted T cells that have NK cell–like properties and bear an invariant T cell receptor (iTCR). iNKT cells have shown potential for cancer immunotherapy. A study now shows that stabilization of the iTCR–CD1d complex via a single-chain bi-specific antibody stimulates iNKT cell ...
Mark A. Exley +2 more
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AIRE deficiency leads to impaired iNKT cell development
Journal of Autoimmunity, 2010Autoimmune Polyendocrine Syndrome type I (APS I) is caused by mutations in the Autoimmune Regulator gene (AIRE), and results in the immunological destruction of endocrine organs. Herein we have characterized the CD1d-restricted invariant NKT cells (iNKT) and NK cells in APS I patients and Aire(-/-) mice, two cell populations known to play a role in the
Emma, Lindh +7 more
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iNKT cells do a fat lot of good
Nature Immunology, 2016Altered signaling via the T cell antigen receptor (TCR) promotes an adipose-tissue-like phenotype in invariant natural killer cells (iNKT cells) during thymic development and causes selective enrichment for iNKT cells in adipose tissues.
Jayati, Mookerjee-Basu +1 more
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