Results 171 to 180 of about 15,268 (219)

A double-edged sword role of IFN-γ-producing iNKT cells in sepsis: Persistent suppression of Treg cell formation in an Nr4a1-dependent manner. [PDF]

iScience
Qin Y, Qian Y, Liu S, Chen R.
europepmc   +1 more source

Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues. [PDF]

Front Immunol
Cui G, Abe S, Kato R, Ikuta K.
europepmc   +1 more source

IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects. [PDF]

iScience
Liu Y, Dang Y, Zhang C, Liu L, Cai W, Li L, Fang L, Wang M, Xu S, Wang G, Zheng J, Li H.   +11 more
europepmc   +1 more source

Immunosuppressive invariant NK T (iNKT) cells [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Severity of critical illness correlates with CD3-low expression on iNKT-cells among septic surgical patients. [PDF]

Inflamm Res
Heffernan DS, Chung CS, Ayala A.
europepmc   +1 more source

Versatile synthesis of C-5" and C-6"-modified α-GalCer analogues as new iNKT cell ligands [PDF]

, 2012
ASPESLAGH, SANDRINE, Elewaut, Dirk, Pauwels, Nora, Van Calenbergh, Serge   +3 more
core   +1 more source

invariant Natural Killer T Cells Modulate the Peritoneal Macrophage Response to Polymicrobial Sepsis. [PDF]

J Surg Res
Heffernan DS, Chun TT, Monaghan SF, Chung CS, Ayala A.   +4 more
europepmc   +1 more source

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Deconstructing iNKT cell development at single-cell resolution

Trends in Immunology, 2022
Invariant natural killer T (iNKT) cells are increasingly regarded as disease biomarkers and immunotherapeutic targets. However, a greater understanding of their biology is necessary to effectively target these cells in the clinic. The discovery of iNKT1/2/17 cell effector subsets was a milestone in our understanding of iNKT cell development and ...
Baranek, Thomas, de Amat Herbozo, Carolina, Mallevaey, Thierry, Paget, Christophe   +3 more
openaire   +3 more sources

Adjuvant activity mediated by iNKT cells

Seminars in Immunology, 2010
Invariant natural killer T (iNKT) cells have adjuvant activity due to their ability to produce large amounts of IFN-gamma, which activates other cells in innate and acquired systems, and orchestrates protective immunity. Based on these adjuvant mechanisms, we developed iNKT cell-targeted adjuvant therapy and carried out a phase I/IIa trial on advanced ...
Shinichiro Motohashi, Toshinori Nakayama, Masaru Taniguchi   +2 more
exaly   +3 more sources