Results 91 to 100 of about 229,257 (276)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.

PLoS ONE, 2010
BackgroundId3 is a dominant antagonist of E protein transcription factor activity that is induced by signals emanating from the alphabeta and gammadelta T cell receptor (TCR).
Mihalis Verykokakis, Markus D Boos, Albert Bendelac, Erin J Adams, Pablo Pereira, Barbara L Kee   +5 more
doaj   +1 more source

SAP-independent and -dependent regulation of innate T cell development involving SLAMF receptors

Frontiers in Immunology, 2014
Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) plays an essential role in the immune system mediating the function of several members of the SLAM family (SLAMF) of receptors, whose expression is essential for T, NK, and B cell ...
Jaime eDe Calisto, Ninghai eWang, Guoxing eWang, Burcu eYigit, Pablo eEngel, Cox eTerhorst   +5 more
doaj   +1 more source

Altered Frequency, Activation, and Clinical Relevance of Circulating Innate and Innate-Like Lymphocytes in Patients With Alcoholic Liver Cirrhosis. [PDF]

Immune Netw, 2023
Park KJ, Jin HM, Cho YN, Yoon JH, Kee SJ, Kim HS, Park YW.   +6 more
europepmc   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

, 2014
The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity ...
Melanie Wencker, Gleb Turchinovich, Livija Deban, Rafael Di Marco Barros, Turchinovich, Gleb, Adrian C Hayday, Cope, Andrew, Hayday, Adrian; id_orcid, Anett Jandke, Jandke, Anett, Wencker, Melanie, DiMarco Barros, Rafael, Andrew Cope, Deban, Livija   +13 more
core   +1 more source

Cancer immunotherapy using γδT cells: dealing with diversity

Frontiers in Immunology, 2014
The broad and potent tumour-reactivity of innate-like γδT cells makes them valuable additions to current cancer immunotherapeutic concepts based on adaptive immunity, such as monoclonal antibodies and αβT cells.
Wouter eScheper, Zsolt eSebestyen, Jürgen eKuball   +2 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses

iScience
Summary: The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination.
Wesley Huisman, Shohreh Azimi, Yen Nhi Nguyen, Alicia C. de Kroon, Karin de Ruiter, Dicky L. Tahapary, Mikhael D. Manurung, Cilia R. Pothast, Yvonne C.M. Kruize, Mirjam H.M. Heemskerk, Taniawati Supali, Leo G. Visser, Anna H.E. Roukens, Maria Yazdanbakhsh, Simon P. Jochems   +14 more
doaj   +1 more source