Results 211 to 220 of about 502,944 (241)

Innate lymphoid cells and innate-like T cells in cancer — at the crossroads of innate and adaptive immunity

Nature Reviews Cancer, 2023
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for many cancers, yet only a subset of patients benefit from these approaches. A better understanding of the complex immune microenvironment of tumours is needed to design the next generation of immunotherapeutics. Innate lymphoid cells (ILCs) and innate-like T cells (
Tim F Greten, Benjamin Ruf, Firouzeh Korangy   +2 more
exaly   +3 more sources

A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells

Cell Stem Cell, 2016
The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-tracing model, we identify a definitive
Tippi C MacKenzie, Anna E Beaudin, Camilla Forsberg   +2 more
exaly   +5 more sources

Development of Novel Ligands That Modulate Innate-Like T Cells

2023
Shinsuke Inuki
exaly   +2 more sources

Regulation of innate-like activities of neonatal CD8+ T cells

Nature Reviews Immunology
Alexandra Flemming
exaly   +3 more sources

Programme of self-reactive innate-like T cell-mediated cancer immunity

Nature, 2022
Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells1-5, and immune checkpoint blockade therapies preferentially target T cells that recognize cancer cell neoantigens6,7. Yet, how other classes of tumour-infiltrating T cells contribute to cancer immunosurveillance remains elusive.
Chun Chou, Xian Zhang, Chirag Krishna, Briana G. Nixon, Saida Dadi, Kristelle J. Capistrano, Emily R. Kansler, Miranda Steele, Jian Han, Amy Shyu, Jing Zhang, Efstathios G. Stamatiades, Ming Liu, Shun Li, Mytrang H. Do, Chaucie Edwards, Davina S. Kang, Chin-Tung Chen, Iris H. Wei, Emmanouil P. Pappou, Martin R. Weiser, J. Garcia-Aguilar, J. Joshua Smith, Christina S. Leslie, Ming O. Li   +24 more
openaire   +2 more sources

Invariant natural killer T cells: innate‐like T cells with potent immunomodulatory activities

Tissue Antigens, 2009
AbstractInvariant natural killer T (iNKT) cells are a subset of T lymphocytes that react with glycolipid antigens presented by the major histocompatibility complex class I‐related glycoprotein CD1d. Although iNKT cells express an antigen‐specific receptor of the adaptive immune system, they behave more like cells of the innate immune system. A hallmark
L, Wu, C L, Gabriel, V V, Parekh, L, Van Kaer   +3 more
openaire   +2 more sources

Fates of Commensal Specific, Innate-like CD8+ T cells in the Gut

The Journal of Immunology, 2023
Abstract Barrier tissues such as the skin and gut are host to a variety of microbes collectively termed the microbiota. To maintain host homeostasis, sufficient exposure to the microbiota is necessary, however, diseases such as Inflammatory Bowel Disease (IBD), have been described as occurring amidst breakdown in the normal communication
Taylor K Farley, Siddharth Krishnamurthy, Fiona Powrie, Yasmine Belkaid   +3 more
openaire   +1 more source

Metabolic control of innate-like T cells

Nature Reviews Immunology
Immunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology. Changes in cellular metabolism help guide the development of thymocytes and the transition of T cells from naive to effector, memory and tissue-resident states.
Thomas Riffelmacher, Mitchell Kronenberg
openaire   +2 more sources