Results 171 to 180 of about 732,201 (216)
Some of the next articles are maybe not open access.
Immunology Letters, 2014
The innate immune response is of prime importance in the immediate recognition and elimination of invading micro-organisms. However, deregulation of this system is clearly associated with the pathogenesis of a wide range of inflammatory diseases. Innate immunity consists of a humoral and a cellular branch, which are closely interacting.
Leo Koenderman
exaly +4 more sources
The innate immune response is of prime importance in the immediate recognition and elimination of invading micro-organisms. However, deregulation of this system is clearly associated with the pathogenesis of a wide range of inflammatory diseases. Innate immunity consists of a humoral and a cellular branch, which are closely interacting.
Leo Koenderman
exaly +4 more sources
Mitochondria in innate immune responses [PDF]
Nature Reviews Immunology, 2011 The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses.
Sankar Ghosh +2 more
exaly +3 more sources
The innate immune response in myocarditis
The International Journal of Biochemistry & Cell Biology, 2021Acute myocarditis is an inflammatory condition of the heart characterised by cellular injury and the influx of leucocytes, including neutrophils, monocytes, macrophages and lymphocytes. While this response is vital for tissue repair, excessive scar deposition and maladaptive ventricular remodelling can result in a legacy of heart failure.
Abdullah Khawaja, Daniel I. Bromage
openaire +3 more sources
Innate Immune Response in Hypertension
Current Pharmaceutical Design, 2022Abstract: Even though an association between inflammation and hypertension has been known for many years, it has not been simple to ascertain the role of several physiological responses involved. The innate immune response plays a critical role in these physiological responses.
openaire +3 more sources
Herpesviruses and the Innate Immune Response
Viral Immunology, 2005Herpesvirus infection leads to the rapid induction of an innate immune response. A central aspect of this host response is the production and secretion of type I interferon. The current model of virus-mediated interferon production includes three stages: sensitization, induction, and amplification.
Karen L, Mossman, Ali A, Ashkar
openaire +2 more sources
Innate Immune Response to Adenovirus
Journal of Investigative Medicine, 2005Adenovirus is a common infectious pathogen in both children and adults. It is a significant cause of morbidity in immunocompetent people living in crowded living conditions and of mortality in immunocompromised hosts. It has more recently become a popular vehicle for gene therapy applications.
Shoab A, Nazir, Jordan P, Metcalf
openaire +2 more sources
The innate immune response to DNA
Seminars in Immunology, 2009As a component of all living cells and microbes, it is not surprising that organisms have evolved mechanisms to detect foreign or aberrant DNA and trigger an innate immune response. TLR9 is an endosomal membrane bound receptor that is widely studied and the best understood DNA sensor. However, the existence of TLR9-independent DNA sensing pathways have
Akosua, Vilaysane, Daniel A, Muruve
openaire +2 more sources
Innate Immune Responses and Osteoarthritis
Current Rheumatology Reports, 2017Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory responses that contribute to OA progression and are the focus
Evangelia, Kalaitzoglou +2 more
openaire +2 more sources
Innate immune responses to infection
Journal of Allergy and Clinical Immunology, 2005The human host survives many infectious challenges in the absence of preexisting specific (adaptive) immunity because of the existence of a separate set of protective mechanisms that do not depend on specific antigenic recognition. These antigen-independent mechanisms constitute innate immunity.
openaire +2 more sources
Sepsis and evolution of the innate immune response
Critical Care Medicine, 2001To review the role of the Toll-like receptors (TLR) as the principal sensors used by the innate immune system in the context of the pathologic processes underlying sepsis and septic shock.Literature review.Through the Toll-like receptors, macrophages and other defensive cells "see" endotoxin (TLR4), peptidoglycan (TLR2), and bacterial DNA (TLR9 ...
B, Beutler, A, Poltorak
openaire +2 more sources