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CNS remyelination and the innate immune system [PDF]
Frontiers in Cell and Developmental Biology, 2016 A misguided inflammatory response is frequently implicated in myelin damage. Particularly prominent among myelin diseases, multiple sclerosis (MS) is an autoimmune condition, with immune–mediated damage central to its aetiology.
Christopher E McMurran +3 more
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Innate immune system and preeclampsia [PDF]
Frontiers in Immunology, 2014 Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection.
Alejandra ePerez-Sepulveda +3 more
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Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]
Mediators of Inflammation, 2016 Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
Kathleen L. McCoy
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Innate Immune Sensing by Cells of the Adaptive Immune System [PDF]
Frontiers in Immunology, 2020 Sensing of microbes or of danger signals has mainly been attributed to myeloid innate immune cells. However, T and B cells also express functional pattern recognition receptors (PRRs).
Tanja Stögerer, Simona Stäger
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The Innate Immune System in Alzheimer’s Disease [PDF]
International Journal of Cell Biology, 2013 Alzheimer’s disease (AD) is the leading cause for dementia in the world. It is characterized by two biochemically distinct types of protein aggregates: amyloid β (Aβ) peptide in the forms of parenchymal amyloid plaques and congophilic amyloid angiopathy (
Allal Boutajangout, Thomas Wisniewski
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Microorganisms, 2021 Vibrosis is one of the major threats in aquaculture farming, and due to the increasing antimicrobial resistance of different Vibrio species, there is an urgent need to replace conventional treatments with more sustainable solutions.
Barbara Rossi +6 more
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Innate immune sensors for detecting nucleic acids during infection
Journal of Laboratory Medicine, 2022 Innate immune receptors detect nucleic acids, such as viruses, and initiate an immune response by secreting interferon (IFN) and regulating IFN-stimulated genes (ISG).
Ghoreshi Zohreh-alsadat +4 more
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Innate Immune Responses to Influenza Virus Infections in the Upper Respiratory Tract
Viruses, 2021 The innate immune system is the host’s first line of immune defence against any invading pathogen. To establish an infection in a human host the influenza virus must replicate in epithelial cells of the upper respiratory tract. However, there are several
Edin J. Mifsud, Miku Kuba, Ian G. Barr
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Systems biology of innate immunity [PDF]
Cellular Immunology, 2006 Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes.
Jesper, Tegnér +4 more
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Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]
, 2020 Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan +3 more
core +1 more source