How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Nature Reviews Immunology, 2021 P. Roy, Marco Orecchioni, K. Ley
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Innate immune sensors for detecting nucleic acids during infection
Journal of Laboratory Medicine, 2022 Innate immune receptors detect nucleic acids, such as viruses, and initiate an immune response by secreting interferon (IFN) and regulating IFN-stimulated genes (ISG).
Ghoreshi Zohreh-alsadat +4 more
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Innate Immune Responses to Influenza Virus Infections in the Upper Respiratory Tract
Viruses, 2021 The innate immune system is the host’s first line of immune defence against any invading pathogen. To establish an infection in a human host the influenza virus must replicate in epithelial cells of the upper respiratory tract. However, there are several
Edin J. Mifsud, Miku Kuba, Ian G. Barr
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Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]
, 2020 Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan +3 more
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Inflammation and Cell Death of the Innate and Adaptive Immune System during Sepsis
Biomolecules, 2021 Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled or abnormal immune response to overwhelming infection. It is now widely accepted that sepsis occurs in two concurrent phases, which consist of an initial immune ...
Christina Nedeva
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Systems biology of innate immunity [PDF]
Cellular Immunology, 2006 Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes.
Jesper, Tegnér +4 more
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Multi-receptor detection of individual bacterial products by the innate immune system
Nature Reviews Immunology, 2017 Karen J. Kieser, Jonathan C. Kagan
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Evolution of innate immune systems* [PDF]
Biochemistry and Molecular Biology Education, 2005 AbstractInnate immunity is the oldest form of defense and is found to some degree in all species. It predates the adaptive immune system, consisting of antibodies, B cells, T cells, and the major histocompatibility antigens. These are found only in higher vertebrates and have been the focus of the majority of immunological research, particularly in ...
Jakob, Suckale +2 more
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Systems biology of innate immunity [PDF]
Immunological Reviews, 2008 Summary: Systems biology is the comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. Systems biology involves an iterative cycle, in which emerging biological problems drive the development of new technologies and computational tools.
Daniel E, Zak, Alan, Aderem
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Engineering physical microenvironments to study innate immune cell biophysics
APL Bioengineering, 2022 Innate immunity forms the core of the human body's defense system against infection, injury, and foreign objects. It aims to maintain homeostasis by promoting inflammation and then initiating tissue repair, but it can also lead to disease when ...
Nikita Kalashnikov, Christopher Moraes
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