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Systems biology of innate immunity [PDF]
Cellular Immunology, 2006 Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes.
Roland Nilsson +4 more
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Evolution of innate immune systems* [PDF]
Biochemistry and Molecular Biology Education, 2005 AbstractInnate immunity is the oldest form of defense and is found to some degree in all species. It predates the adaptive immune system, consisting of antibodies, B cells, T cells, and the major histocompatibility antigens. These are found only in higher vertebrates and have been the focus of the majority of immunological research, particularly in ...
Jakob Suckale +2 more
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The Chemokine System in Innate Immunity [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Chemokines are chemotactic cytokines that control the migration and positioning of immune cells in tissues and are critical for the function of the innate immune system. Chemokines control the release of innate immune cells from the bone marrow during homeostasis as well as in response to infection and inflammation.
Andrew D. Luster, Caroline L. Sokol
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Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity
Frontiers in Immunology, 2019 Granzymes (Gzm) are serine proteases, contained into the secretory granules of cytotoxic cells, responsible for the cell-mediated cytotoxicity (CMC) against tumor cells and intracellular pathogens such as virus and bacteria.
Elena Chaves-Pozo +8 more
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System of innate immunity in plants [PDF]
Molecular Biology, 2011 The review deals with the mechanisms of innate immunity in plants with a focus on families of pattern-recognition receptors and regard for recent data on complete sequencing of the genomes of several plant species. Plants utilize several families of such receptors, both membrane-bound and cytoplasmic ones, which contain conservative leucine-rich ...
Olga A. Vakhrusheva +3 more
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The Evasion of Antiviral Innate Immunity by Chicken DNA Viruses
Frontiers in Microbiology, 2021 The innate immune system constitutes the first line of host defense. Viruses have evolved multiple mechanisms to escape host immune surveillance, which has been explored extensively for human DNA viruses. There is growing evidence showing the interaction
Li Gao, Shijun Zheng, Yongqiang Wang
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Systems biology of innate immunity [PDF]
Immunological Reviews, 2008 Summary: Systems biology is the comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. Systems biology involves an iterative cycle, in which emerging biological problems drive the development of new technologies and computational tools.
Daniel E. Zak, Alan Aderem
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Fish Peroxiredoxins and Their Role in Immunity
Biology, 2015 Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from oxidative damage. In addition, Prxs may act as modulators of inflammation, protect against cell death and tumour progression, and facilitate tissue repair after damage. The
Yulema Valero +4 more
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Getting on in Old Age: How the Gut Microbiota Interferes With Brain Innate Immunity
Frontiers in Cellular Neuroscience, 2021 The immune system is crucial for defending against various invaders, such as pathogens, cancer cells or misfolded proteins. With increasing age, the diminishing immune response, known as immunosenescence, becomes evident.
Omar Mossad, Omar Mossad, Thomas Blank
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Fishes, 2018 Stress is one of the main problems of farmed fish, where it has been seen to result in a variety of disorders and negative effects. It is considered very important to minimize such effects and one option is the use of dietary additives.
Daniel Gonzalez-Silvera +3 more
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