Results 21 to 30 of about 1,386,634 (347)

Engineering physical microenvironments to study innate immune cell biophysics

APL Bioengineering, 2022
Innate immunity forms the core of the human body's defense system against infection, injury, and foreign objects. It aims to maintain homeostasis by promoting inflammation and then initiating tissue repair, but it can also lead to disease when ...
Nikita Kalashnikov, Christopher Moraes
doaj   +1 more source

Leprosy and Immune System An Insight into the Innate Immune System [PDF]

, 2021
Innate immunity is a host immune mechanism to defend itself promptly. It includes physical and chemical barriers, cells in the circulation and tissues, several plasma proteins, and immune cells constituting phagocytic cells (monocytes/macrophages and ...
Budiamal, S, Christopher, PM, Putri, Winawati Eka   +2 more
core  

Chronic wounds alter the proteome profile in skin mucus of farmed gilthead seabream

BMC Genomics, 2017
Background Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However,
Héctor Cordero, Monica F. Brinchmann, Alberto Cuesta, María A. Esteban   +3 more
doaj   +1 more source

Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?

Frontiers in Aging Neuroscience, 2021
Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging.
Md. Mahiuddin Ahmed, Md. Mahiuddin Ahmed, Md. Mahiuddin Ahmed, Noah R. Johnson, Noah R. Johnson, Noah R. Johnson, Timothy D. Boyd, Timothy D. Boyd, Timothy D. Boyd, Christina Coughlan, Christina Coughlan, Christina Coughlan, Heidi J. Chial, Heidi J. Chial, Heidi J. Chial, Huntington Potter, Huntington Potter, Huntington Potter   +17 more
doaj   +1 more source

The Innate Immune System and Transplantation [PDF]

Cold Spring Harbor Perspectives in Medicine, 2013
The sensitive and broadly reactive character of the innate immune system makes it liable to activation by stress factors other than infection. Thermal and metabolic stresses experienced during the transplantation procedure are sufficient to trigger the innate immune response and also augment adaptive immunity in the presence of foreign antigen on the ...
Farrar, Conrad A, Kupiec-Weglinski, Jerzy W, Sacks, Steven H   +2 more
openaire   +4 more sources

Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity

Frontiers in Immunology, 2019
Granzymes (Gzm) are serine proteases, contained into the secretory granules of cytotoxic cells, responsible for the cell-mediated cytotoxicity (CMC) against tumor cells and intracellular pathogens such as virus and bacteria.
Elena Chaves-Pozo, Yulema Valero, Yulema Valero, Maria Teresa Lozano, Pablo Rodríguez-Cerezo, Liang Miao, Vittorio Campo, Maria Angeles Esteban, Alberto Cuesta   +8 more
doaj   +1 more source

Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion

Frontiers in Microbiology, 2021
Hepatitis viruses are primary causative agents of hepatitis and represent a major source of public health problems in the world. The host innate immune system forms the first line of defense against hepatitis viruses.
Chonghui Xu, Chonghui Xu, Jizheng Chen, Jizheng Chen, Xinwen Chen, Xinwen Chen   +5 more
doaj   +1 more source

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

The Role of the Immune System in the Pathophysiology of Essential Hypertension

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2022
Hypertension (HTN) is a critical worldwide health issue and an imperative risk factor for the development of cardiovascular disease and kidney disease. There are many crevices in our knowledge about the pathophysiology of HTN.
Mahsa Rekabi, Zahra Daneshmandi, Elham Sadati, Mahsa Mirzendehdel, Seyed Alireza Mahdaviani, Ali Valinejadi, Ali Akbar Velayati, Parisa Honarpisheh   +7 more
doaj   +1 more source

Aging of the innate immune system [PDF]

Current Opinion in Immunology, 2010
The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like
Albert C, Shaw, Samit, Joshi, Hannah, Greenwood, Alexander, Panda, Janet M, Lord   +4 more
openaire   +2 more sources