Results 111 to 120 of about 287,222 (242)

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria

, 2020
International audienceInborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease. We report a patient with mycobacterial disease due to inherited deficiency of the transcription factor T-bet.
Ogishi, Masato, Errami, Abderrahmane, Croft, Carys, Oleaga-Quintas, Carmen, Rahman, Mahbuba, Kerner, Gaspard, Sallusto, Federica, Marr, Nico, Al Ali, Fatima, Bustamante, Jacinta, Bousfiha, Aziz, Batteux, Fréderic, Ailal, Fatima, Bourgey, Mathieu, Seeleuthner, Yoann, Weisshaar, Marc, Quintana-Murci, Lluis, Di Santo, James, Glimcher, Laurie, Maclsaac, Julia, Boisson-Dupuis, Stéphanie, Gruber, Conor, Zhang, Peng, Jeljeli, Mohamed, Worley, Lisa, Langlais, David, Doisne, Jean-Marc, Rozenberg, Flore, Kobor, Michael, Rosain, Jérémie, Roynard, Manon, El Baghdadi, Jamila, Latorre, Daniela, Bogunovic, Dusan, Ma, Cindy, Pan-Hammarström, Qiang, Tangye, Stuart, Shen, Yichao, Carroll, Thomas, Elarabi, Houda, Markle, Janet, Puel, Anne, Jarrossay, David, Husquin, Lucas, Benhsaien, Ibithal, Abel, Laurent, Casanova, Jean-Laurent, Yang, Rui, Gros, Philippe, Mele, Federico, Khan, Taushif, Han, Jing   +51 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Assessing lineage and cytolytic functional potential of murine tissue-resident innate lymphocytes. [PDF]

STAR Protoc, 2023
Nixon BG, Chou C, Li MO.
europepmc   +1 more source

Differential effects of age on chicken heterophil functional activation by recombinant chicken interleukin-2

, 2002
Interleukin-2 (IL-2) exercises an array of biological effects on many cells including the functional activation of cells of the innate immune response.
Pete Kaiser, Kogut, Michael, Michael Kogut, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Development of human plasmacytoid dendritic cells and innate lymphoid cells [PDF]

, 2018
Innate immune cells play crucial role in the front line of defense against pathogens and harmful substances to protect the human body. One particular subtype are the innate lymphocytes which are characterized by an absence of rearranged antigen specific ...
Nagasawa, M.
core   +1 more source

Microbial Antigens Stimulate Metalloprotease-7 Secretion in Human B-Lymphocytes Using mTOR-Dependent and Independent Pathways

Scientific Reports, 2017
Metalloproteinases (MMPs) contribute to tissue remodeling and acute inflammation not only by degrading extracellular matrix proteins but also by controlling the influx of chemokines through the regulation and shedding of syndecans.
Mohamed F. Ali, Harika Dasari, Virginia P. Van Keulen, Divi Cornec, George Vasmatzis, Tobias Peikert, Eva M. Carmona   +6 more
doaj   +1 more source

Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata. [PDF]

Elife, 2023
Laufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar A.   +5 more
europepmc   +1 more source

microRNAs in the control of lymphocytes response

, 2009
Recently, it has become evident the importance of miRNAs in regulating immune response, as well as immune cell development. During my phD fellow I focused my attention on the relationship B-lymphocytes-microRNA; in particular I examined two the different
Rossi, Annalisa
core  

Les lymphocytes du tissu adipeux humain : caractérisation et rôles [PDF]

, 2009
L'obésité est associée à un état inflammatoire systémique de bas niveau et à une production excessive de cytokines pro-inflammatoires dans le tissu adipeux (TA).
Duffaut, Carine
core