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HiJAKing Innate Lymphoid Cells? [PDF]

Frontiers in Immunology, 2017
The family of innate lymphoid cells (ILCs) consists of a heterogeneous group of cytokine-producing cells that have features in common with adaptive T helper (Th) cells. Cytokines acting through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways are key players in both Th and ILC biology.
SCIUME', GIUSEPPE, Le, Mimi T, Gadina, Massimo   +2 more
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Human innate lymphoid cells [PDF]

Journal of Allergy and Clinical Immunology, 2016
Innate lymphoid cells (ILCs) are increasingly acknowledged as important mediators of immune homeostasis and pathology. ILCs act as early orchestrators of immunity, responding to epithelium-derived signals by expressing an array of cytokines and cell-surface receptors, which shape subsequent immune responses.
Jenny Mjösberg, Hergen Spits
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Innate Lymphoid Cell Immunometabolism [PDF]

Journal of Molecular Biology, 2017
Innate lymphoid cells (ILCs) are tissue-resident "first responders" of the immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. However, because ILCs are finely tuned to perturbations within tissue microenvironments, they can also contribute to host pathology when upstream activating signals are ...
Timothy E, O'Sullivan, Joseph C, Sun
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Innate lymphoid cell memory [PDF]

Cellular & Molecular Immunology, 2019
Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, NK cells recall haptens, viruses ...
Xianwei, Wang, Hui, Peng, Zhigang, Tian
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[Innate lymphoid cells].

Medecine sciences : M/S, 2017
Innate Lymphoid Cells (ILC) are tissue-resident effector lymphocytes that differ from the B and T lymphocytes subsets since they lack specific antigen receptors derived from gene rearrangements. They can be divided into two groups, cytotoxic ILC (NK cells) which are dependent on the transcription factors Eomes and T-bet and produce IFN-γ, and helper ...
Crinier, Adeline, Viant, Charlotte, Girard-Madoux, Mathilde, Vivier, Eric   +3 more
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Enrichment of innate lymphoid cell populations in gingival tissue [PDF]

, 2018
Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual
Adrados Planell, A., Brown, J.L., Butcher, J.P., Campbell, L., Culshaw, S., Malcolm, J.   +5 more
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SnapShot: Innate Lymphoid Cells

Immunity, 2013
ILC1 α4β7+ α4β7SnapShot: Innate Lymphoid Cells Gregory F. Sonnenberg,1,3 Jenny Mjosberg,4 Hergen Spits,5 and David Artis2,3 1Departments of Medicine and 2Microbiology, 3Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 4Karolinska University Hospital Huddinge, Karolinska Institutet, Sweden 5Tytgat Institute for Liver ...
Sonnenberg, Gregory F., Mjösberg, Jenny, Spits, Hergen, Artis, David   +3 more
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NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice [PDF]

, 2018
Innate lymphoid cells (ILCs) producing IL-22 and/or IL-17, designated as ILC3, comprise a heterogeneous subset of cells involved in regulation of gut barrier homeostasis and inflammation.
Kanno, Yuka, Mikami, Yohei, O'Shea, John J, Santoni, Angela, SCARNO, GIANLUCA, Sciumè, Giuseppe, Shih, Han-Yu, Zitti, Beatrice   +7 more
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Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. [PDF]

, 2019
Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in ...
Cameron, Guy JM, Cautivo, Kelly M, Deshpande, Aniruddh V, Foster, Paul S, Hansbro, Philip M, Jiang, Simon H, Loering, Svenja, McKenzie, Andrew NJ, Molofsky, Ari B, Starkey, Malcolm R   +9 more
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Innate lymphoid cells and cancer

Nature Immunology, 2022
The innate lymphoid cell (ILC) family is composed of natural killer (NK) cells, ILC1, ILC2 and ILC3, which participate in immune responses to virus, bacteria, parasites and transformed cells. ILC1, ILC2 and ILC3 subsets are mostly tissue-resident, and are profoundly imprinted by their organ of residence.
Jacquelot, Nicolas, Seillet, Cyril, Vivier, Eric, Belz, Gabrielle   +3 more
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