Results 111 to 120 of about 131,532 (293)

Innate lymphoid cells and fibrotic regulation

, 2018
Innate lymphoid cells (ILCs) are innate immune cells that do not possess B or T cell receptors but belong to the lymphoid lineage. While these cells have not yet been extensively investigated since their classification as a homogenous group, emerging ...
Horsburgh, Steven, O'Reilly, Steven, Jörg H.W. Distler, Todryk, Stephen, Steven Horsburgh, Ramming, Andreas, Andreas Ramming, Stephen Todryk, Distler, Jorg HW, Steven O’Reilly, Distler, Jörg   +10 more
core   +1 more source

Optimized Protocol for Characterization of Mouse Gut Innate Lymphoid Cells

, 2020
© 2020 Valle-Noguera, Gómez-Sánchez, Girard-Madoux and Cruz-Adalia.Since their discovery, innate lymphoid cells (ILCs) have gradually been gaining greater relevance in the field of immunology due to their multiple functions in the innate immune response.
Valle-Noguera, Ana, Gómez Sánchez, María José, Girard-Madoux, Mathilde J. H., Girard-Madoux, Mathilde J H, Gómez-Sánchez, María José, Cruz-Adalia, Aránzazu, Valle Noguera, Ana, Girard Madoux, Mathilde J. H., Cruz Adalia, Aranzazu   +8 more
core   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Innate Lymphoid Cells in Protection, Pathology, and Adaptive Immunity During Apicomplexan Infection

Frontiers in Immunology, 2019
Apicomplexans are a diverse and complex group of protozoan pathogens including Toxoplasma gondii, Plasmodium spp., Cryptosporidium spp., Eimeria spp., and Babesia spp.
Daria L. Ivanova, Stephen L. Denton, Kevin D. Fettel, Kerry S. Sondgeroth, Juan Munoz Gutierrez, Berit Bangoura, Ildiko R. Dunay, Jason P. Gigley   +7 more
doaj   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Editorial: ILC checkpoints: expression and functions in physiological and pathological conditions

Frontiers in Immunology, 2023
Francesca Romana Mariotti, Nadia Guerra, Ana Stojanovic, Ana Stojanovic, Linda Quatrini   +4 more
doaj   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Innate Lymphoid Cells: Immunoregulatory Cells of Mucosal Inflammation

European Journal of Inflammation, 2014
Inflammation is a very complex immunopathological process occurring due to exaggerated activation of immune system in response to various inflammatory stimuli (i.e.
V. Kumar
doaj   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Ontogeny of innate T lymphocytes - some innate lymphocytes are more innate then others

Frontiers in Immunology, 2014
Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is innate in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and
David eVermijlen, Immo ePrinz
doaj   +1 more source