Results 151 to 160 of about 130,824 (258)

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

RAG1 deficiency durably alters dermal group 2 innate lymphoid cells and modifies contact hypersensitivity. [PDF]

Front Immunol
Saleh MM, Liao K, Braun A, Salinas G, Schön MP, Dasari P, Buhl T.   +6 more
europepmc   +1 more source

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

Peyer's patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22. [PDF]

Nat Immunol
Cao WHJ, You Y, Wang N, Chaudhry MZ, Yu H, Bell PT, Noye EC, Denman R, Lee B, Waddington A, Ye J, Schreuder J, Huang Q, Tellier J, Curio S, Santiago J, Amann-Zalcenstein D, Jacquelot N, Hickey P, Nutt SL, Seillet C, Hansbro PM, Wimmer VC, Strugnell RA, Tuong ZK, Ritchie ME, Belz GT.   +26 more
europepmc   +1 more source

A Nitric Oxide–Based STING Agonist Nanoadjuvant With ICD‐Derived Membrane Antigens Unleashes Robust Antitumor Immunity

Exploration, EarlyView.
Schematic illustration of the synergistic antitumor mechanism of Im@NOnanoPL combined with αPD‐1 therapy. The Im@NOnanoPL nanovaccine targets lymph nodes via ICD‐derived tumor cell membranes, delivering personalized tumor antigens. It releases NO gas to enhance MHC‐I expression and activate the STING pathway, thereby potentiating anti‐tumor immunity in
Shuyu Xu, Yang Song, Tianjiao Zhang, Yan Wang, Mengxin Wang, Xinxin Xie, Qingfeng Chen, Xiaolong Liang   +7 more
wiley   +1 more source

Ziyuglycoside I promotes wound healing via GPR34-mediated activation of group 3 innate lymphoid cells. [PDF]

Chin Med
Wang K, Sun Q, Wang G, Zhang J, Wang Y, Jiang B, Zhang Y.   +6 more
europepmc   +1 more source

Type 3 innate lymphoid cells dominate the ILC compartment in endstage lung disease. [PDF]

Front Immunol
Halle O, Falke JN, Kessemeier C, Lobjanidze K, Fuchshuber E, Brüske S, Gaedcke S, Schumacher M, Dähne L, Knaup J, Borghorst M, Pallenberg S, Albrecht M, Jirmo AC, Bergmann J, Paulsen M, Jonigk D, Braubach P, Dittrich AM.   +18 more
europepmc   +1 more source

Identification, characterization, and expansion of innate lymphoid cells derived from canine peripheral blood mononuclear cells. [PDF]

Front Immunol
Mehrani Y, Chan L, McKenna C, Eng-Toogood M, Freitas FP, Vanderboon E, Woods JP, Bridle BW, Karimi K.   +8 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source