Results 161 to 170 of about 130,824 (258)

Heterogeneity and clinical relevance of group 2 innate lymphoid cells subsets in nasal polyps. [PDF]

J Allergy Clin Immunol
Kidoguchi M, Iwasaki N, Poposki JA, Ogasawara N, Oka A, Klingler AI, Suh L, Agrwal A, Bai J, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS, Johnson M, Radwan A, Conley DB, Schleimer RP, Kern RC, Tan BK, Okano M, Fujieda S, Kato A.   +22 more
europepmc   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

T helper 17 cells and group 3 innate lymphoid cells define a spectrum of psoriasis endotypes. [PDF]

Front Immunol
Schön MP.
europepmc   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

Correction: Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma

Journal of Experimental & Clinical Cancer Research
Francesca De Mitri, Manuela Giansanti, Ombretta Melaiu, Dorothee Haas, Stefan Ebert, Nicola Tumino, Elisabetta Vulpis, Francesca Gatto, Beatrice Martuscelli, Manuela Antonioli, Elisabetta Sangiuliano, Simona Caruso, Marco Scarsella, Cristiano De Stefanis, Veronica Marabitti, Silvia Campello, Doriana Fruci, Paola Vacca, Ignazio Caruana, Francesca Nazio   +19 more
doaj   +1 more source

The role of nasal microbiota and type 2 innate lymphoid cells in the pathogenesis of allergic rhinitis. [PDF]

Biochem Biophys Rep
Wang C, Zhang YM, Zhou ML, Li M, Cheng KJ.   +4 more
europepmc   +1 more source

Tissue Clearing for Lymph Nodes: 3D Mapping of Nerves and the Immune Microenvironment

iNew Medicine, EarlyView.
ABSTRACT Lymph nodes (LNs) are central hubs of adaptive immunity and key relay sites for metastatic tumour cells. However, conventional two‐dimensional histology samples only a small fraction of each node, potentially missing micrometastases and multifocal involvement while obscuring long‐range spatial relationships among tumour deposits, immune ...
Guang‐Hong Su, Fei Wang, Ting‐Hong Wei, Rui Lu, Wen‐Jun Huang, Xiang Zhang, Ling Yin, Jun Li   +7 more
wiley   +1 more source

Amplification cycles through innate lymphoid cells at the onset of lupus nephritis. [PDF]

Front Immunol
Kreider RL, Biniaris-Georgallis SI, Grothey B, Triantafyllopoulou A, Steinheuer LM, Thurley K.   +5 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Transcription factor BHLHE40 expression in group 3 innate lymphoid cells and RORγt⁺ antigen-presenting cells coordinates intestinal immunity. [PDF]

Immunity
Yang W, Pires S, Cardakli E, Nagayama M, Scott C, Tran N, Oguntunmibi S, Bradstreet TR, Webber AM, Astorkia M, Betel D, Diehl G, Edelson BT, Longman RS.   +13 more
europepmc   +1 more source