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The discovery of innate lymphoid cells
Nature Reviews Immunology, 2021Eric Vivier describes the unexpected discovery of new populations of innate-like lymphocytes and the development of the innate lymphoid cell nomenclature.
Eric Vivier
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Innate lymphoid cell development
Journal of Allergy and Clinical Immunology, 2021Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and regulate tissue homeostasis and immunity. ILCs are divided into 3 groups, group 1 ILCs, group 2 ILCs, and group 3 ILC3, on the basis of their similar effector programs to T cells. The development of ILCs from lymphoid progenitors in adult mouse bone marrow has been studied in detail ...
Maryam, Ghaedi, Fumio, Takei
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The Innate Lymphoid Cell Precursor
Annual Review of Immunology, 2016The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing ...
Albert Bendelac +1 more
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The biology of innate lymphoid cells
Nature, 2015The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate
David Artis, Hergen Spits
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Development of innate lymphoid cells
Nature Immunology, 2016Innate lymphoid cells (ILCs) are a family of immune effector cells that have important roles in host defense, metabolic homeostasis and tissue repair but can also contribute to inflammatory diseases such as asthma and colitis. These cells can be categorized into three groups on the basis of the transcription factors that direct their function and the ...
Erin C, Zook, Barbara L, Kee
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Innate Lymphoid Cells in Cancer
Cancer Immunology Research, 2015AbstractThe world of lymphocytes has recently expanded. A group of cells, innate lymphoid cells (ILC), has been defined. It includes lymphoid cells that have been known for decades, such as natural killer (NK) cells and lymphoid tissue–inducer (LTi) cells. NK cells recognize a vast array of tumor cells, which they help to eliminate through cytotoxicity
B. Vallentin +9 more
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The diversified class of immune cells known as innate lymphoid cells (ILCs), which lack altered antigen-specific receptors, is essential for the maintenance of immunological homeostasis, tissue repair, and protection against pathogens. They are the innate counterparts of CD4+ Th cells.
Ann Mary, Joseph +2 more
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Ann Mary, Joseph +2 more
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Innate lymphoid cells in atherosclerosis
European Journal of Pharmacology, 2017The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions.
Daniel, Engelbertsen, Andrew H, Lichtman
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Blood, 2014
Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development ...
M. D. Hazenberg, H. Spits
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Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development ...
M. D. Hazenberg, H. Spits
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Innate Lymphoid Cells of the Lung
Annual Review of Physiology, 2019Although, as the major organ of gas exchange, the lung is considered a nonlymphoid organ, an interconnected network of lung-resident innate cells, including epithelial cells, dendritic cells, macrophages, and natural killer cells is crucial for its protection. These cells provide defense against a daily assault by airborne bacteria, viruses, and fungi,
Jillian L, Barlow, Andrew N J, McKenzie
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