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Innate lymphoid cells and asthma
Journal of Allergy and Clinical Immunology, 2014Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype characterized by TH2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes, such as asthma associated with exposure to air pollution, infection, or obesity, that
Sanhong, Yu +4 more
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2020
Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
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Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
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Plasticity of innate lymphoid cell subsets
Nature Reviews Immunology, 2020Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can be categorized into five subsets with defined phenotypes and functional profiles, but they also have the ability to adapt to local environmental cues by changing these ...
Suzanne M. Bal +2 more
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Immunophenotyping of Human Innate Lymphoid Cells
2019In the last years, the family of innate lymphocytes has been growing following the discovery of innate lymphoid cells (ILCs). ILCs are lymphocytes able to rapidly produce a wide range of soluble mediators in an antigen-independent fashion. So far, three main subsets of ILCs have been discovered, ILC1, ILC2, and ILC3, expressing respectively the ...
Trabanelli, Sara +2 more
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Immunity without innate lymphoid cells
Nature Immunology, 2016A cohort of immunodeficient children lead near-normal lives after bone marrow transplantation, despite a profound deficiency of innate lymphoid cells (ILCs).
Weinkove, Robert +2 more
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Innate lymphoid cells and fibrotic regulation
Immunology Letters, 2018Innate lymphoid cells (ILCs) are innate immune cells that do not possess B or T cell receptors but belong to the lymphoid lineage. While these cells have not yet been extensively investigated since their classification as a homogenous group, emerging evidence suggests that they exert significant regulatory roles in both tissue remodelling and ...
Horsburgh, Steven +4 more
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Innate Lymphoid Cells: The Innate Counterpart to T Helper Cells
2016Innate lymphoid cells (ILCs) are a recently discovered subset of innate immune cells that are capable of secreting great amounts of cytokines that have been found to influence effector cell activity. Chronic rhinosinusitis (CRS) in the absence (CRSsNP) or presence (CRSwNP) of nasal polyps has been characterized as type 1- and type 2-skewed ...
Caroline, Padro Dietz, Amber, Luong
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2016
Retinoic acid receptor-related (RAR) orphan receptor γ (Rorγt) innate lymphoid cells or group 3 innate lymphoid cells (ILC3s) play key roles in the development of lymphoid tissues, maintenance of epithelial tissue homeostasis, and repair and defense against pathogens encountered at the body's barriers.
Belz, Gabrielle T. +4 more
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Retinoic acid receptor-related (RAR) orphan receptor γ (Rorγt) innate lymphoid cells or group 3 innate lymphoid cells (ILC3s) play key roles in the development of lymphoid tissues, maintenance of epithelial tissue homeostasis, and repair and defense against pathogens encountered at the body's barriers.
Belz, Gabrielle T. +4 more
openaire +3 more sources
Skin-resident innate lymphoid cells converge on a pathogenic effector state
Nature, 2021Amanda Kedaigle +2 more
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