Results 121 to 130 of about 9,113,445 (285)

Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

open access: yesNature Communications, 2016
Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the ...
Néstor Saiz   +3 more
doaj   +1 more source

Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

open access: yes, 2014
The transcription factor Oct4 is required in vitro for establishment and maintenance of embryonic stem cells and for reprogramming somatic cells to pluripotency. In vivo, it prevents the ectopic differentiation of early embryos into trophoblast. Here, we
Etienne-Dumeau, Charles   +12 more
core   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

open access: yesAdvanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez   +9 more
wiley   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

open access: yesAdvanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal   +21 more
wiley   +1 more source

Non-smooth nonlinearities as restoring forces in a mass-in-mass cell

open access: yes, 2022
International audienceThe energy exchanges between particles of a mass-in-mass cell with nonlinear restoring forcing function are studied. Two types of non-smooth compound nonlinearities are considered as restoring forcing function acting on the inner ...
Dufour, Régis   +3 more
core   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

open access: yesAdvanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker   +7 more
wiley   +1 more source

FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea [PDF]

open access: yes, 2002
Neural transmission of complex sounds demands fast and sustained rates of synaptic release from the primary cochlear receptors, the inner hair cells (IHCs). The cells therefore require efficient membrane recycling.
Ashmore, JF   +2 more
core  

Nitride MXenes Beyond Carbides: Bridging the Gap Between Computational Prediction and Experimental Realization

open access: yesAdvanced Functional Materials, EarlyView.
Nitride MXenes remain constrained by a persistent gap between computational prediction and experimental realization. This Review identifies the thermodynamic, kinetic, and chemical barriers limiting their synthesis, critically evaluates emerging fabrication routes, and proposes a multidimensional computational‐experimental framework to accelerate the ...
Naresh Varnakavi, Masoud Soroush
wiley   +1 more source

2k-inner products and 2k-Riemannian metrics [PDF]

open access: yes, 2000
The notion of 2k-inner product is introduced as a generalization of usual inner product and Q-inner product([4]-[8]). As a consequence, is defined the notion of 2k-normed space and some properties, e.g. uniformly convexity, Gâteaux differentiability and
Dragomir, Sever S, Crasmareanu, Mircea
core   +1 more source

Effect of Different Exposure Periods to The Infrared 1.48 μm Diode Laser on the Inner Cell Mass and Trophectoderm of Blastocysts

open access: yesSiriraj Medical Journal, 2002
This study was carried out to determine the effect of the duration of exposure to an infrared 1.48 μm diode laser, on the number of cells in the inner cell mass and the trophectoderm of blastocysts following laser-assisted embryo biopsy.
Phakphum Phophong   +2 more
doaj  

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