Results 71 to 80 of about 9,113,445 (285)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Inner Cell Mass Development

, 2020
Following fertilization, the mammalian embryo self-organizes into a hollow ball of cells, the blastocyst. The first two cell types that appear within the blastocyst are known as trophoblast and inner cell mass (ICM). Trophoblast will form placenta, while
Zach McLean (15401048), Bjorn Oback (15395243)   +1 more
core  

Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B [PDF]

, 2010
Apicomplexan parasites belong to a recently recognised group of protozoa referred to as Alveolata. These protists contain membranous sacs (alveoli) beneath the plasma membrane, termed the Inner Membrane Complex (IMC) in the case of Apicomplexa.
Bernardo J. Foth, Ferguson, D.J. P., Markus Meissner, David J. P. Ferguson, Foth, B.J., Carolina Agop-Nersesian, Langsley, G., Saskia Egarter, Meissner, M., Egarter, S., Sibley, L.D., Bernardo J Foth, Gordon Langsley, Agop-Nersesian, C., David J P Ferguson, Foth Bernardo J., Meissner Markus, Agop-Nersesian Carolina, Egarter Saskia, Langsley Gordon, Ferguson David J. P.   +20 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

The trophectoderm acts as a niche for the inner cell mass through C/EBPa-regulated IL-6 signaling

, 2022
IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown.
de Andres-Aguayo, Luisa, Vila-Casadesus, Maria, Serrano, Manuel, Plana-Carmona, Marcos, Francesconi, Mirko, Segura-Morales, Carolina, Bulteau, Romain, Torcal Garcia, Guillem, Stik, Gregoire, Plachta, Nicolas, Tian, Tian, Gasnier, Maxime, Wyatt, Chris DR, Alcazar, Noelia, Graf, Thomas, Klonizakis, Antonios   +15 more
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Ekspresi gen Bax pada kultur in vitro Inner Cell Mass (ICM) mencit

, 2021
Inner Cell Mass (ICM) merupakan sumber sel punca embrionik (ESC, embryonic stem cell). Inner Cell Mass dapat diisolasi dari embrio tahap blastosis yang kemudian dikultur secara in vitro untuk mendapatkan koloni ESC.
Arif Wibowo, Holy, Rinendyaputri, Ratih
core   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source