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Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance [PDF]

Molecules, 2018
The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies.
Sho Kanzaki
doaj   +2 more sources

Inner ear morphology in the Atlantic molly Poecilia mexicana [PDF]

, 2011
Fishes show an amazing diversity in hearing abilities, inner ear structures, and otolith morphology. Inner ear morphology, however, has not yet been investigated in detail in any member of the diverse order Cyprinodontiformes.
Tanja Schulz‐Mirbach, Martin Heß, Martin Plath   +2 more
openalex   +4 more sources

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]

Stem Cell Reports, 2019
Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang, Alpha L. Alex, Jing Nie, Jiyoon Lee, Adam A. Roth, Kevin T. Booth, Karl R. Koehler, Eri Hashino, Rick F. Nelson   +8 more
doaj   +3 more sources

Biomaterial-based drug delivery systems in the treatment of inner ear disorders [PDF]

Journal of Nanobiotechnology
Inner ear disorders are among the predominant etiology of hearing loss. The blood-labyrinth barrier limits the ability of drugs to attain pharmacologically effective concentrations within the inner ear; consequently, delivering drugs systemically is ...
Hong Cheng, Bin Zhang, Pei Jiang, Menghui Liao, Xin Gao, Dongyu Xu, Yusong Wang, Yangnan Hu, Huan Wang, Tingting Liu, Renjie Chai   +10 more
doaj   +2 more sources

Rational Design of Inner Ear Drug Delivery Systems [PDF]

Advanced Science
The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well as a huge social burden. Among these patients, hearing loss caused by inner ear lesions accounts for a large proportion. Therefore,
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
doaj   +2 more sources

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

Scientific Reports, 2021
Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu, Jin Woong Choi, Yasuko Ishibashi, Kevin Isgrig, Mhamed Grati, Jean Bennett, Wade Chien   +6 more
doaj   +1 more source

Fzd3 Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding

Frontiers in Neuroscience, 2022
During development the afferent neurons of the inner ear make precise wiring decisions in the hindbrain reflective of their topographic distribution in the periphery.
Zachary A. Stoner, Elizabeth M. Ketchum, Sydney Sheltz-Kempf, Paige V. Blinkiewicz, Karen L. Elliott, Jeremy S. Duncan, Jeremy S. Duncan   +6 more
doaj   +1 more source

Inner ear malformation

Listy klinicke logopedie, 2020
Inner ear malformation comprises a broad group of disorders, the main symptom of which is hearing loss. The disorder occurs during the embryonic development of the auditory system. Only about 20 % of malformations can be diagnosed radiologically. Hearing
Dagmar Hošnová, Milan Urík
doaj   +1 more source

Nanocarriers for Inner Ear Disease Therapy

Frontiers in Cellular Neuroscience, 2021
Hearing loss is a common disease due to sensory loss caused by the diseases in the inner ear. The development of delivery systems for inner ear disease therapy is important to achieve high efficiency and reduce side effects.
Xiaoxiang Xu, Xiaoxiang Xu, Jianwei Zheng, Yanze He, Kun Lin, Shuang Li, Ya Zhang, Peng Song, Yuye Zhou, Yuye Zhou, Xiong Chen   +10 more
doaj   +1 more source

The inner ear and the neurologist [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2007
Inner ear disorders are common and patients with vestibular failure often present to a neurology clinic because of their dizziness, gait unsteadiness and oscillopsia. Vestibular disorders can be divided into peripheral and central vestibular disorders.
Charlotte, Agrup, Michael, Gleeson, Peter, Rudge   +2 more
openaire   +2 more sources