Results 1 to 10 of about 432,936 (357)

Dual contribution to amplification in the mammalian inner ear [PDF]

Phys. Rev. Lett. 105, 118102 (2010), 2010
The inner ear achieves a wide dynamic range of responsiveness by mechanically amplifying weak sounds. The enormous mechanical gain reported for the mammalian cochlea, which exceeds a factor of 4,000, poses a challenge for theory. Here we show how such a large gain can result from an interaction between amplification by low-gain hair bundles and a ...
A. J. Hudspeth, J. Lighthill, L. Robles, M. A. Ruggero, Tobias Reichenbach   +4 more
arxiv   +3 more sources

The Role of FoxG1 in the Inner Ear [PDF]

Frontiers in Cell and Developmental Biology, 2020
Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem.
Yanyan Ding, Wei Meng, Weijia Kong, Zuhong He, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai   +7 more
doaj   +4 more sources

Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish [PDF]

Biomedicines
Background: Alternative splicing is essential for the physiological and pathological development of the inner ear. Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss.
Mengmeng Ren, Xiang Chen, Liyan Dai, Jiayi Tu, Hualei Hu, Xiaohan Sun, Jiong Luo, Pei Li, Yiyang Fu, Yuejie Zhu, Weiqiang Sun, Zhaohui Tang, Mugen Liu, Xiang Ren, Qunwei Lu   +14 more
doaj   +2 more sources

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]

Stem Cell Reports, 2019
Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang, Alpha L. Alex, Jing Nie, Jiyoon Lee, Adam A. Roth, Kevin T. Booth, Karl R. Koehler, Eri Hashino, Rick F. Nelson   +8 more
doaj   +3 more sources

Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review [PDF]

Journal of Otology
The inner ear sensory epithelium consists of two major types of cells: hair cells (HCs) and supporting cells (SCs). Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated.
Jing-Ying Guo, Jun-Yi Xu, Shu-Sheng Gong, Guo-Peng Wang   +3 more
doaj   +2 more sources

Precision medicine: a new era for inner ear diseases [PDF]

Frontiers in Pharmacology
The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani, Elisa Tavazzani, Paolo Spaiardi, Paolo Spaiardi, Donatella Contini, Giulio Sancini, Giulio Sancini, Giancarlo Russo, Sergio Masetto   +8 more
doaj   +2 more sources

Modeling, applications and challenges of inner ear organoid [PDF]

Smart Medicine
More than 6% of the world's population is suffering from hearing loss and balance disorders. The inner ear is the organ that senses sound and balance. Although inner ear disorders are common, there are limited ways to intervene and restore its sensory ...
Jieyu Qi, Liyan Zhang, Xiaohan Wang, Xin Chen, Yiyuan Li, Tian Wang, Peina Wu, Renjie Chai   +7 more
doaj   +2 more sources

Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review. [PDF]

PLoS One
Hearing loss is a significant health burden across all stages of life. One in 5 people suffer hearing loss, with 5% of the world's population experiencing disabling hearing loss.
Creber NJ, Muzaffar J, Gowrishankar S, Borsetto D, Phillips V, Smith ME.   +5 more
europepmc   +3 more sources

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

Scientific Reports, 2021
Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu, Jin Woong Choi, Yasuko Ishibashi, Kevin Isgrig, Mhamed Grati, Jean Bennett, Wade Chien   +6 more
doaj   +1 more source

Fzd3 Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding

Frontiers in Neuroscience, 2022
During development the afferent neurons of the inner ear make precise wiring decisions in the hindbrain reflective of their topographic distribution in the periphery.
Zachary A. Stoner, Elizabeth M. Ketchum, Sydney Sheltz-Kempf, Paige V. Blinkiewicz, Karen L. Elliott, Jeremy S. Duncan, Jeremy S. Duncan   +6 more
doaj   +1 more source