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The Role of FoxG1 in the Inner Ear [PDF]
Frontiers in Cell and Developmental Biology, 2020 Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem.
Yanyan Ding +7 more
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Communications Medicine, 2021 Plain language summary Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the novel coronavirus SARS-CoV-2. A growing number of sensory symptoms have been linked to this illness.
Minjin Jeong +15 more
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Biomaterial-based drug delivery systems in the treatment of inner ear disorders [PDF]
Journal of NanobiotechnologyInner ear disorders are among the predominant etiology of hearing loss. The blood-labyrinth barrier limits the ability of drugs to attain pharmacologically effective concentrations within the inner ear; consequently, delivering drugs systemically is ...
Hong Cheng +10 more
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Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]
Stem Cell Reports, 2019 Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang +8 more
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Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture. [PDF]
PLoS ONE, 2016 Stem cell-derived inner ear sensory epithelia are a promising source of tissues for treating patients with hearing loss and dizziness. We recently demonstrated how to generate inner ear sensory epithelia, designated as inner ear organoids, from mouse ...
Rachel E DeJonge +5 more
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Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish [PDF]
BiomedicinesBackground: Alternative splicing is essential for the physiological and pathological development of the inner ear. Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss.
Mengmeng Ren +14 more
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The Blood-Labyrinth Barrier: Non-Invasive Delivery Strategies for Inner Ear Drug Delivery [PDF]
PharmaceuticsThe inner ear is a relatively isolated organ, protected by the blood-labyrinth barrier (BLB). This barrier creates a unique lymphatic fluid environment within the inner ear, maintaining a stable physiological state essential for the mechano-electrical ...
Zhangyi Yi +3 more
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Inner Ear Therapeutics: An Overview of Middle Ear Delivery
Frontiers in Cellular Neuroscience, 2019 There are a variety of methods to access the inner ear and many of these methods depend on utilizing the middle ear as a portal. In this approach the middle ear can be used as a passive receptacle, as part of an active drug delivery system, or simply as ...
Jaimin Patel +6 more
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Rational Design of Inner Ear Drug Delivery Systems [PDF]
Advanced ScienceThe number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well as a huge social burden. Among these patients, hearing loss caused by inner ear lesions accounts for a large proportion. Therefore,
Xiayidan Maimaitikelimu +5 more
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Scientific Reports, 2021 Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu +6 more
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