Results 11 to 20 of about 1,559,915 (394)

Fzd3 Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding

Frontiers in Neuroscience, 2022
During development the afferent neurons of the inner ear make precise wiring decisions in the hindbrain reflective of their topographic distribution in the periphery.
Zachary A. Stoner, Elizabeth M. Ketchum, Sydney Sheltz-Kempf, Paige V. Blinkiewicz, Karen L. Elliott, Jeremy S. Duncan, Jeremy S. Duncan   +6 more
doaj   +1 more source

Nanocarriers for Inner Ear Disease Therapy

Frontiers in Cellular Neuroscience, 2021
Hearing loss is a common disease due to sensory loss caused by the diseases in the inner ear. The development of delivery systems for inner ear disease therapy is important to achieve high efficiency and reduce side effects.
Xiaoxiang Xu, Xiaoxiang Xu, Jianwei Zheng, Yanze He, Kun Lin, Shuang Li, Ya Zhang, Peng Song, Yuye Zhou, Yuye Zhou, Xiong Chen   +10 more
doaj   +1 more source

Inner ear malformation

Listy klinicke logopedie, 2020
Inner ear malformation comprises a broad group of disorders, the main symptom of which is hearing loss. The disorder occurs during the embryonic development of the auditory system. Only about 20 % of malformations can be diagnosed radiologically. Hearing
Dagmar Hošnová, Milan Urík
doaj   +1 more source

Age-Related Hearing Loss Is Dominated by Damage to Inner Ear Sensory Cells, Not the Cellular Battery That Powers Them

Journal of Neuroscience, 2020
Age-related hearing loss arises from irreversible damage in the inner ear, where sound is transduced into electrical signals. Prior human studies suggested that sensory-cell loss is rarely the cause; correspondingly, animal work has implicated the stria ...
P. Wu, J. O'malley, V. De Gruttola, M. C. Liberman   +3 more
semanticscholar   +1 more source

Inner Ear Gene Therapies Take Off: Current Promises and Future Challenges

Journal of Clinical Medicine, 2020
Hearing impairment is the most frequent sensory deficit in humans of all age groups, from children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital deafness are hereditary in nature.
S. Delmaghani, A. El-Amraoui
semanticscholar   +1 more source

Exosomes mediate sensory hair cell protection in the inner ear.

Journal of Clinical Investigation, 2020
Hair cells are the mechanosensory receptors of the inner ear, responsible for hearing and balance. Hair cell death and consequent hearing loss are common results of treatment with ototoxic drugs, including the widely-used aminoglycoside antibiotics ...
Andrew M. Breglio, Lindsey A. May, M. Barzik, Nora Welsh, Shimon P. Francis, Tucker Costain, Lizheng Wang, D. Eric Anderson, Ronald S. Petralia, Ya‐Xian Wang, Thomas B. Friedman, Matthew J.A. Wood, Lisa L. Cunningham   +12 more
semanticscholar   +1 more source

Editorial: Neuroimmunology of the Inner Ear [PDF]

Frontiers in Neurology, 2021
© 2021 Perin, Marino, Varela-Nieto and Szczepek. Although the term was first officially used in 1982 (1), neuroimmunology is now a mature field that has gained immense traction in the past decade. Thanks to novel technological advances, the cellular and molecular mechanisms that mediate the crosstalk between the immune and nervous systems are ...
Paola Perin, Franca Marino, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto, Agnieszka J. Szczepek, Agnieszka J. Szczepek   +6 more
openaire   +7 more sources

Drug Delivery across Barriers to the Middle and Inner Ear

Advanced Functional Materials, 2020
The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat these conditions. Here, recent advances in drug delivery systems that access the ear through the tympanic membrane (TM) are reviewed.
Zipei Zhang, Xiyu Li, Wei Zhang, D. Kohane   +3 more
semanticscholar   +1 more source

The inner ear and the neurologist [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2007
Inner ear disorders are common and patients with vestibular failure often present to a neurology clinic because of their dizziness, gait unsteadiness and oscillopsia. Vestibular disorders can be divided into peripheral and central vestibular disorders.
Michael Gleeson, Peter Rudge, Charlotte Ågrup   +2 more
openaire   +3 more sources

The Mechanosensory Transduction Machinery in Inner Ear Hair Cells.

Annual Review of Biophysics, 2020
Sound-induced mechanical stimuli are detected by elaborate mechanosensory transduction (MT) machinery in highly specialized hair cells of the inner ear.
Wang Zheng, J. R. Holt
semanticscholar   +1 more source