Results 91 to 100 of about 315,665 (286)

Traffic to the inner membrane of the nuclear envelope

Current Opinion in Cell Biology, 2014
Past research has yielded valuable insight into the mechanisms that regulate the nuclear transport of soluble molecules like transcription factors and mRNA. Much less is known about the mechanisms responsible for the transportation of membrane proteins to the inner membrane of the nuclear envelope. The key question is: does the facilitated transport of
Laba, Justyna K, Steen, Anton, Veenhoff, Liesbeth M   +2 more
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Primary envelopment of Kaposi’s sarcoma-associated herpesvirus at the nucleoplasmic reticulum

Journal of Virology
Herpesvirus egress begins with primary envelopment of newly assembled capsids at the inner nuclear membrane (INM). Primary envelopment has been observed at the peripheral INM as well as nuclear infoldings. Nuclear infoldings from invaginations of the INM
Alexa Wilson, Neale D. Ridgway, Craig McCormick   +2 more
doaj   +1 more source

Nuclear envelopathies: a complex LINC between nuclear envelope and pathology

Orphanet Journal of Rare Diseases, 2017
Since the identification of the first disease causing mutation in the gene coding for emerin, a transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants have been found in genes encoding for nuclear envelope components ...
Alexandre Janin, Delphine Bauer, Francesca Ratti, Gilles Millat, Alexandre Méjat   +4 more
doaj   +1 more source

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles [PDF]

, 2016
Survivin, the smallest member of the inhibitor of apoptosis protein family, plays a central role during mitosis and exerts a cytoprotective function. Survivin is highly expressed in most cancer types and contributes to multiple facets of carcinogenesis ...
Beghein, Els, De Ganck, Ariane, Gettemans, Jan, Van Audenhove, Isabel, Verhelle, Adriaan, Zwaenepoel, Olivier   +5 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The protein import apparatus of chloroplasts [PDF]

, 1993
Routing of cytosolically synthesized precursor proteins into chloroplasts is a specific process which involves a multitude of soluble and membrane components.
Bartling D., Bassham D. C., Buvinger W. E., Cline K., Cline K., Cline K., Heike Alefsen, Joyard J., Jürgen Soll, Kirwin P. M., Li H.‐M., Mould R. M., Olsen L. J., Olsen L. J., Perry S. E., Pilon M., Schnell D. J., Theg S. M.   +17 more
core   +1 more source

Inner nuclear membrane protein transport is mediated by multiple mechanisms [PDF]

Biochemical Society Transactions, 2008
Work in the nuclear transport field has led to an incredibly detailed description of protein translocation through the central channel of the nuclear pore complex, yet the mechanism by which nuclear envelope transmembrane proteins reach the inner nuclear membrane after synthesis in the endoplasmic reticulum is still hotly debated.
Zuleger, Nikolaj, Korfali, Nadia, Schirmer, Eric C   +2 more
openaire   +2 more sources

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source