Results 41 to 50 of about 307,971 (276)
Nuclear lipids: key signaling effectors in the nervous system and other tissues1
Journal of Lipid Research, 2004 Lipids have long been recognized as quantitatively minor components of the nucleus, where they were initially thought to have little functional importance; but they now command growing interest, with recognition of their diverse signaling and modulating ...
Robert W. Ledeen, Gusheng Wu
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Towards understanding inner nuclear membrane protein degradation in plants
Journal of Experimental Botany, 2022 AbstractThe inner nuclear membrane (INM) hosts a unique set of membrane proteins that play essential roles in various aspects of the nuclear function. However, overaccumulation or malfunction of INM protein has been associated with a range of rare genetic diseases; therefore, maintaining the homeostasis and integrity of INM proteins by active removal ...
Enrico Calvanese, Yangnan Gu
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Early sorting of inner nuclear membrane proteins is conserved [PDF]
Proceedings of the National Academy of Sciences, 2007 Spodoptera frugiperda (Sf9) importin-α-16 is a translocon-associated protein that participates in the early sorting pathway of baculovirus integral membrane proteins destined for the inner nuclear membrane (INM). To discern whether sorting intermediate protein complexes like those observed in insect cells are also formed with ...
Sharon C, Braunagel +4 more
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Active Nuclear Import of Membrane Proteins Revisited
Cells, 2015 It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where ...
Justyna K. Laba +5 more
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The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
Cell, 2018 Summary The inner nuclear membrane (INM) encases the genome and is fused with the outer nuclear membrane (ONM) to form the nuclear envelope. The ONM is contiguous with the endoplasmic reticulum (ER), the main site of phospholipid synthesis.
Anete Romanauska, A. Köhler
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MICROTUBULATION OF THE INNER MEMBRANE OF THE NUCLEAR ENVELOPE [PDF]
The Journal of Cell Biology, 1961 In the course of a light and electron microscopy study of spermatogenesis in the European crayfish, Astacus fluviatilis, spermatocytes of abnormal appearance were observed in two instances in individuals that had passed the mating period. The electron microscope showed that the inner membrane of the nuclear envelope of these cells was erupting into a ...
G A, MEEK, M J, MOSES
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Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
Nature Communications, 2019 Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they ...
Kazunori Kume +3 more
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Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress
Proceedings, 2020 During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova +3 more
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Viruses, 2015 Herpes simplex virus 1 (HSV-1) capsids are assembled in the nucleus bud at the inner nuclear membrane into the perinuclear space, acquiring envelope and tegument. In theory, these virions are de-enveloped by fusion of the envelope with the outer nuclear
Peter Wild +6 more
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Generating Membrane Curvature at the Nuclear Pore: A Lipid Point of View
Cells, 2022 In addition to its structural role in enclosing and protecting the genome, the nuclear envelope (NE) forms a highly adaptive communication interface between the cytoplasm and the nuclear interior in eukaryotic cells.
Bas W. A. Peeters +2 more
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