Results 81 to 90 of about 260,266 (297)

Effect of corruption and political instability on enterprises’ innovativeness in Ethiopia: pooled data based

Journal of Innovation and Entrepreneurship, 2019
The aim of this study is to investigate the effects of corruption and political instability on Ethiopian enterprises’ innovativeness based on pooled data from 644 and 848 enterprises (manufacturing, retailing, and non-retailing services) surveyed in 2011
Arega Shumetie, Mulugeta Damie Watabaji
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Influence of Customer Perceived Restaurant Innovativeness (CPRI) of Meatball Restaurants on Brand Love and Brand Loyalty

Indonesian Interdisciplinary Journal of Sharia Economics
The highly competitive landscape among food and beverage entrepreneurs in Indonesia compels brands to compete aggressively to attract and retain customers.
Qorina Firkiana, Kurniawati Kurniawati, Yolanda Masnita   +2 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Distinguishing Online Opinion Leaders

Asia Marketing Journal, 2017
This article empirically examines the relationship between values, consumer innovativeness, online opinion leadership, and new product adoption behavior utilizing wearable technology as the overall unit of analysis.
Yukyung Lee, Minjung Park, Subin Im
doaj   +1 more source

Innovative Method to Control Dubas Bug, Ommatissus lybicus (Deberg) (Homoptera: Tropiduchidae) in Date Palm Orchards Using Endophytic Beauveria bassiana Isolates [PDF]

, 2016
Mohammad Waleed Khudhair, Hussain F. Alrubeai, Mohammed Zaidan Khalaf   +2 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Unlocking the power of endogenous factors for small business success. The role of knowledge management towards innovation

Journal of Innovation and Entrepreneurship
Small businesses play a crucial role in the economic development of both developed and developing countries. The purpose of this study is to gain a deeper understanding of the relationship between knowledge management and innovation, and how it can be ...
Tilahun Getnet Mirete, Samuel Godadaw Ayinaddis   +1 more
doaj   +1 more source

The Innovation Innovation

, 2009
We seek explanation for how a species with our complex social systems could have arisen. We argue that an “innovation innovation” took place during hominin evolution that decoupled organizational change from a Darwinian evolutionary process and underlies the forms of social organization we find in human societies today.
D. Read, LANE, David Avra, S. van der Leeuw   +2 more
openaire   +3 more sources