Results 11 to 20 of about 378,797 (150)

Inorganic Pyrophosphatase–Nanodiamond Conjugates Hydrolyze Pyrophosphate in Human Synovial Fluid [PDF]

ACS Omega, 2020
Anastasiya V. Valueva, Roman S. Romanov, Sofia S. Mariasina, Maxim S. Eliseev, Elena V. Rodina   +4 more
doaj   +2 more sources

Phosphatase kinetics reveal mechanistic pathways of soil phosphorus recovery during long-term desert revegetation [PDF]

iScience
Summary: Phosphorus (P) limitation constrains dryland restoration, yet how phosphatase kinetics regulate soil P recovery remains unclear.
Mingzhu He, Chunming Xin, Chengyi Li, Huijun Qin, Jing Zhou, Shengzhong Du   +5 more
doaj   +2 more sources

Synthesis of Inorganic Pyrophosphatase–Nanodiamond Conjugates Resistant to Calcium and Fluoride [PDF]

ACS Omega, 2020
Anastasiya V. Valueva, Roman S. Romanov, Nataliya N. Vorobyeva, Svetlana A. Kurilova, Elena V. Rodina   +4 more
doaj   +2 more sources

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism [PDF]

FEBS Open Bio
In Thermus thermophilus, an aerobic Gram‐negative eubacterium used as a model organism, more than half of the phosphorylation sites identified by proteomic analysis are located near the ligand‐binding site, including the active site, of the enzyme in the
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
doaj   +2 more sources

Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2. [PDF]

Am J Hum Genet, 2016
We have used whole-exome sequencing in ten individuals from four unrelated pedigrees to identify biallelic missense mutations in the nuclear-encoded mitochondrial inorganic pyrophosphatase (PPA2) that are associated with mitochondrial disease.
Kennedy H, Haack TB, Hartill V, Mataković L, Baumgartner ER, Potter H, Mackay R, Alston CL, O'Sullivan S, McFarland R, Connolly G, Gannon C, King R, Mead S, Crozier I, Chan W, Florkowski CM, Sage M, Höfken T, Alhaddad B, Kremer LS, Kopajtich R, Feichtinger RG, Sperl W, Rodenburg RJ, Minet JC, Dobbie A, Strom TM, Meitinger T, George PM, Johnson CA, Taylor RW, Prokisch H, Doudney K, Mayr JA.   +34 more
europepmc   +3 more sources

Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase

mBio, 2023
Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez, Beate Schwer, Nikolaus Jork, Henning J. Jessen, Stewart Shuman   +4 more
doaj   +1 more source

PPA2 Deficiency in 2 Sisters

JACC: Case Reports, 2023
Inorganic pyrophosphatase 2 (PPA2) deficiency is a genetic cause of sudden cardiac death, often triggered by viral infection or alcohol consumption. Literature on management is limited because most cases are diagnosed post mortem.
Will Genthe, MS, Colleen Donnelly, MS, David Ezon, MD, Veronica Fettig, MS, Jaya Ganesh, MD, Isaac Marin-Valecia, MD, Bruce D. Gelb, MD   +6 more
doaj   +1 more source

Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression

mBio, 2022
Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1,5-IP8 derepress the PHO regulon while mutations that ablate IP8 synthesis are PHO ...
Bradley Benjamin, Angad Garg, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman   +5 more
doaj   +1 more source

Downregulation of PPA2 expression correlates with poor prognosis of kidney renal clear cell carcinoma [PDF]

PeerJ, 2021
Background Kidney renal clear cell carcinoma (KIRC) is the most common subtype of kidney cancer. Inorganic pyrophosphatase (PPA2) is an enzyme that catalyzes the hydrolysis of pyrophosphate to inorganic phosphate; few studies have reported its ...
Wenbiao Zhu, Huiming Jiang, Shoucheng Xie, Huanqin Xiao, Qinghua Liu, Nanhui Chen, Pei Wan, Shanming Lu   +7 more
doaj   +2 more sources

Matrix Vesicle-Associated SMS2 as a Novel Mediator of Biomineralization. [PDF]

J Extracell Biol
ABSTRACT SGMS2, a gene encoding plasma membrane‐resident sphingomyelin synthase 2, SMS2, has emerged as an important determinant of skeletal ossification. Heterozygous SGMS2 variants are associated with a broad spectrum of bone phenotypes, ranging from rickets‐like deformities in childhood to early‐onset osteoporosis, implicating SMS2 in mineralization
Newton PT, Brunet MY, Marchan-Alvarez JG, Mäkitie O, Holthuis JCM.   +4 more
europepmc   +2 more sources