Results 131 to 140 of about 86,294 (302)

Results of a Multicenter Study on the Efficacy and Safety of Inosine Glycyl-Cysteinyl-Glutamate Disodium in the Treatment of Acute Ethanol Poisoning

, 2022
И. А. Шикалова, A. N. Lodyagin, В. Г. Антонов, A. Yu. Simonova, N. B. Loginova, E. V. Baskakov, L. G. Zaitseva, В. В. Шилов, S. P. Katasonov   +8 more
openalex   +2 more sources

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, EarlyView.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source

Comparison of the effects of copper chlorophyllin, riboxin, indralin and the combined use of glutathione and ascorbic acid on the survival of mice during fractionated X-ray irradiation

Разработка и регистрация лекарственных средств
Introduction. The problem of effectiveness and safe pharmacological means of reducing the consequences of exposure to the ionizing effect is becoming increasingly urgent.
L. A. Romodin, A. A. Moskovskij, O. V. Nikitenko, T. M. Bychkova, E. D. Rodionova   +4 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Formation of tRNA Wobble Inosine in Humans Is Disrupted by a Millennia-Old Mutation Causing Intellectual Disability

Molecular and Cellular Biology, 2019
The formation of inosine at the wobble position of eukaryotic tRNAs is an essential modification catalyzed by the ADAT2/ADAT3 complex. In humans, a valine-to-methionine mutation (V144M) in ADAT3 that originated ∼1,600 years ago is the most common cause ...
Jillian Ramos, Lu Han, Yan Li, Felix Hagelskamp, Stefanie M. Kellner, F. Alkuraya, E. Phizicky, Dragony Fu   +7 more
semanticscholar   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

An Untargeted Metabolomic Analysis of Lacticaseibacillus (L.) rhamnosus, Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum and Limosilactobacillus (L.) reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus

Microorganisms
Lactic acid bacteria are considered an inexhaustible source of bioactive compounds; indeed, products from their metabolism are known to have immunomodulatory and anti-inflammatory activity.
Luca Spaggiari, Natalia Pedretti, Francesco Ricchi, Diego Pinetti, Giuseppina Campisciano, Francesco De Seta, Manola Comar, Samyr Kenno, Andrea Ardizzoni, Eva Pericolini   +9 more
doaj   +1 more source

Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents.

Organic Letters, 2019
New chemical probes have been designed to facilitate the identification of adenosine-to-inosine (A-to-I) edited RNAs. These reagents combine a conjugate acceptor for selective inosine covalent modification with functional groups for bioorthogonal ...
Ying Li, M. Göhl, K. Ke, C. Vanderwal, R. Spitale   +4 more
semanticscholar   +1 more source

A UK key opinion leader perspective: Navigating the immunological and logistical transformation brought by stem cell‐derived islets for the treatment of type 1 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims To explore UK key‐opinion leader perspectives on the future role of stem cell‐derived islets (sc‐islets) in islet transplantation for people with type 1 diabetes (T1D). Methods Four UK‐based key‐opinion leaders evaluated current limitations of donor islet transplantation and reviewed emerging evidence, clinical pathways and logistical ...
Thomas Strakosch, Shareen Forbes
wiley   +1 more source

Application of Liquid Chromatography Coupled to Mass Spectrometry for Direct Estimation of the Total Levels of Adenosine and Its Catabolites in Human Blood

Pharmaceuticals
Adenosine is a multifunctional nucleoside with several roles across various levels in organisms. Beyond its intracellular involvement in cellular metabolism, extracellular adenosine potently influences both physiological and pathological processes.
Jakub Šofranko, Peter Mitro, Zora Lazúrová, Martin Jozef Péč, Tomáš Bolek, Renata Péčová, Matúš Dohál, Matej Samoš, Radovan Murín   +8 more
doaj   +1 more source