Results 141 to 150 of about 270,142 (371)

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer [PDF]

, 2019
Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival.
Alzayady, Kamil J., Ando, Hideaki, Bartok, Adam, Bánsághi, Száva, Csordás, György, Golenár, Tünde, Hajnóczky, György, Joseph, Suresh K., Katona, Máté, Mikoshiba, Katsuhiko, Nichtova, Zuzana, Thomas, V. Kaye, Weaver, David, Yule, David I.   +13 more
core   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

A Ca$^{2+}$ puff model based on integrodifferential equations [PDF]

arXiv
The calcium (Ca$^{2+}$) signalling system is important for many cellular processes within the human body. Signals are transmitted within the cell by releasing Ca$^{2+}$ from the endoplasmic reticulum (ER) into the cytosol via clusters of Ca$^{2+}$ channels.
arxiv  

Revisiting double diffusion encoding MRS in the mouse brain at 11.7T: which microstructural features are we sensitive to? [PDF]

arXiv, 2019
Brain metabolites, such as N-acetylaspartate or myo-inositol, are constantly probing their local cellular environment under the effect of diffusion. Diffusion-weighted NMR spectroscopy therefore presents unparalleled potential to yield cell-type specific microstructural information.
arxiv  

Note on the Fermentation of i-Inositol [PDF]

, 1921
James Arthur Hewitt, Dorothy B. Steabben
openalex   +1 more source

Buckwheat - an old crop with new health prospects [PDF]

, 2007
Interest in buckwheat has incresed due to it being a valuable raw material for functional food production. It has been reported to have general beneficial effects on health. Buckwheat competes well with weeds and suffers little from other pests.
Keskitalo, Marjo, Ketoja, Elise, Kontturi, Markku, Mäki, Maarit, Pihlava, Juha-Matti, Rantamäki, Pirjo, Tupasela, Tuomo   +6 more
core  

Inositol synthesis: concise preparation of l-chiro-inositol and muco-inositol from a common intermediate

Tetrahedron: Asymmetry, 1998
Abstract Fully stereoselective large-scale syntheses have been attained for l - chiro -inositol ( 2 ) and muco -inositol ( 3 ) by means of controlled peripheral oxygenation of cyclohexadiene diol 1 .
Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA ( host institution ), Brammer, Larry E ( author ), Hudlicky, Tomas ( author )   +2 more
openaire   +3 more sources

A Mosaic Hotspot PLCD1 Variant, Detectable in Blood‐Derived DNA, Associated With Nevus Trichilemmocysticus

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
Leanne de Kock, Macarena Nougues, Madeline Couse, Wendy Mears, Alison J. Eaton, Kristin D. Kernohan, Care4Rare Canada Consortium, Margarita Larralde, Kym M. Boycott   +8 more
wiley   +1 more source

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recombinant adeno associated virus (rAAV) vectors have become popular delivery vehicles for in vivo gene therapies, but demand for rAAVs continues to outpace supply. Platform processes for rAAV production are being developed by many manufacturers, and transient chemical transfection of human embryonic kidney 293 (HEK293) cells is currently the
Erica A. Green, Qiang Fu, Nelson Ndahiro, Thomas M. Leibiger, Yongdan Wang, Yongsuk Lee, Kelvin H. Lee, Michael Betenbaugh, Seongkyu Yoon, David J. McNally   +9 more
wiley   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source