Results 141 to 150 of about 132,246 (241)

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Cyclitols and Aminocyclitols as Signals: Their Roles in Supporting Ecosystems and Promoting Human Health. [PDF]

J Nat Prod
Skala L, Murdach PK, Hennelly T, Mahmud T.   +3 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Effects of dietary myo-inositol supplementation on the expression of fibroblast growth factor 23 (FGF23) and αKlotho in two commercial laying hen strains. [PDF]

Poult Sci
Meier L, Szentgyörgyi Á, Wallauch N, Feger M, Oster M, Sommerfeld V, Schmucker S, Huber K, Stefanski V, Wimmers K, Rodehutscord M, Föller M.   +11 more
europepmc   +1 more source

Investigation into the delivery and evaluation of a unique Avena sativa (Oat) Lipid Extract on skin barrier using LC‒MS/MS, Raman spectroscopy, immunostaining analysis and skin efficacy

International Journal of Cosmetic Science, EarlyView.
Abstract Objectives Oat lipids are rich in ceramides. In this investigation, we analysed the delivery of a specific Oat Lipid Extract derived from Avena sativa, comprising ‘skin identical’ ratios of fatty acids, ceramides and cholesterol/sterol. This investigation is the first reported investigation of oat lipids utilizing Raman spectroscopy for the ...
E. Gombert, C. Dewis
wiley   +1 more source

<i>In ovo</i> myo-inositol administration: impacts on growth performance and metabolic profiles in broiler chickens. [PDF]

Front Physiol
Shomina N, Sommerfeld V, Rodehutscord M, Huber K.   +3 more
europepmc   +1 more source

Annual Research Review: Neural mechanisms of eating disorders in youth – from current theory and findings to future directions

Journal of Child Psychology and Psychiatry, EarlyView.
Eating disorders are prevalent and profoundly debilitating psychiatric conditions with multifactorial etiology that frequently manifest during adolescence. This developmental stage is characterized by significant neurostructural and neurofunctional change, which may create a context conducive to the emergence of eating pathology.
Kelsey Hagan, E. Caitlin Lloyd, Sasha Gorrell   +2 more
wiley   +1 more source

Neuropeptide SP protects against colitis and linked anxiety-like behavior through the putative roles of gut microbiota and metabolite inositol. [PDF]

Nat Commun
Lan J, Wang J, Huang S, Li C, Deng Z, Hao Z, Ma Y.   +6 more
europepmc   +1 more source

First attempt at using a synthetic diet in short‐lived killifish, a vertebrate model of ageing

Journal of Fish Biology, EarlyView.
Abstract Diet standardization of model organisms is crucial for experimental consistency and repeatability in laboratory research, yet laboratory fish often lack species‐specific, open‐formula standardized diets. This study aims to address this gap by testing the effect of macronutrient content on the performance of Nothobranchius furzeri, an ...
Jakub Žák, Milan Vrtílek
wiley   +1 more source

A minimum catalytic unit for synthesis of InsP6 and 5-PP-InsP5 in Arabidopsis. [PDF]

Biochem J
Whitfield HL, Sprigg C, Riley AM, Potter BVL, Kuo HF, Brearley CA.   +5 more
europepmc   +1 more source