Results 101 to 110 of about 1,279,181 (240)

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Distribution of Inositol 1,4,5-Trisphosphate Receptors in Rat Osteoclasts

ACTA HISTOCHEMICA ET CYTOCHEMICA, 2008
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are Ca2+ channels that localize to intracellular Ca2+ stores such as the endoplasmic reticulum (ER). Recently, IP3Rs were found to participate in the formation of the cytoskeleton and cellular adhesions. In this study, we examined the cellular localization of type I, II, and III IP3Rs to assess their
Morikawa, Kazumasa, Goto, Tetsuya, Tanimura, Akihiko, Kobayashi, Shigeru, Maki, Kenshi   +4 more
openaire   +3 more sources

Distribution of the inositol 1,4,5-trisphosphate receptor, P400, in adult rat brain

, 2013
The distribution of the inositol 1,4,5-trisphosphate receptor protein, P400, was investigated in adult rat brain by immunocytochemistry with the monoclonal antibody 4C11 raised against mouse cerebellar inositol 1,4,5- trisphosphate receptor protein ...
Mikoshiba, Katsuhiro, Suburo, Ángela M., Bentura, M. L., Fernández, T., Martínez-Murillo, Ricardo, Polak, J. M., Rodrigo García, José, Nakade, Shinji   +7 more
core   +1 more source

Inositol pyrophosphate kinases in health and disease

FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.
In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen, Chenglai Fu   +6 more
wiley   +1 more source

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

eLife, 2016
Selective elimination of unwanted synapses is vital for the precise formation of neuronal circuits during development, but the underlying mechanisms remain unclear.
Junhua Yang, Hongbin Yang, Yali Liu, Xia Li, Liming Qin, Huifang Lou, Shumin Duan, Hao Wang   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, Volume 600, Issue 17, Page 2547-2563, September 2026.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

Molecular Neurodegeneration, 2012
Background Huntington's Disease (HD) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (Htt) containing an expanded polyglutamine (polyQ) tract.
Bauer Peter O, Hudec Roman, Goswami Anand, Kurosawa Masaru, Matsumoto Gen, Mikoshiba Katsuhiko, Nukina Nobuyuki   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Inositol 1,4,5 trisphosphate (IP3) receptor.

Folia Pharmacologica Japonica, 2003
The intensive molecular and biochemical study of IP(3)R has made great progress in elucidating the following unique properties of IP(3)R: 1) IP(3) dependent Ca(2+) release is quantal in nature; 2) IP(3)R allosterically and dynamically changes its form; 3) IP(3)R is functional even though it is fragmented by proteases into several pieces; 4) IP(3)R ...
openaire   +3 more sources