Results 111 to 120 of about 1,279,181 (240)

ORGN 684-Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate [PDF]

, 2007
The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not ...
Conway, Stuart John, Bultynck, G, Roderick, H. L.Lewelyn, Aslam, Tashfeen, Bultynck, Geert, Roderick, H. Llewellyn, Conway, Stuart J., Slawin, Alexandra M Z, Roderick, H L, Roderick, H. Llewelyn, Bootman, MD, Slawin, AM, Bello, Davide, Bootman, M D, Roderick, HL, Aslam, Tashfeen; id_orcid, Conway, Stuart, Slawin, Alexandra Martha Zoya, Slawin, Alexandra M.Z., Bello, D, Aslam, T, Conway, SJ, Slawin, A M Z, Slawin, AMZ, Bootman, Martin D., Slawin, Alexandra M. Z.   +25 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1817-1830, September 2026.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Recognition of myo-inositol 1,4,5-trisphosphate using a fluorescent imidazolium receptor

, 2019
The first example of an imidazolium-based fluorescent receptor for d-myo-inositol 1,4,5-trisphosphate (IP 3) is reported in this study. The fluorescent receptor 1 bearing four imidazolium and pyrene groups displayed a large fluorescent quenching effect ...
권용억, 윤주영
core   +1 more source

Synthesis and Biological Action of Novel 4-Position-Modified Derivatives of d-myo-Inositol 1,4,5-Trisphosphate

, 2016
The design of a range of 4-position-modified d-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not ...
Stuart J. Conway (1280553), Geert Bultynck (313679), Alexandra M. Z. Slawin (809268), Davide Bello (2483887), Martin D. Bootman (363159), Tashfeen Aslam (2483890), H. Llewelyn Roderick (58841)   +6 more
core   +2 more sources

Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons

Biomolecules
The endoplasmic reticulum (ER) is a key organelle in cellular homeostasis, regulating calcium levels and coordinating protein synthesis and folding. In neurons, the ER forms interconnected sheets and tubules that facilitate the propagation of calcium ...
Vyacheslav M. Shkryl
doaj   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, Volume 13, Issue 54, 28 September 2026.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

, 2002
Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 muM). This new IP3K inhibitor 1 increased Ca2+ ion release as a result
Choi, Gildon, Gray, NS, Cox, RJ, Moon, Ho-Sang, Choi, Kwan Yong, Chung, SK, Ryu, Sung Ho, Burdett, Matthew, Gray, Nathanael S., Chung, Sung-Kee, Ryu, SH, Suh, PG, Bae, Yoe-Sik, Schultz, Peter G., Choi, G, Meijer, Laurent, Mogk, Axel, Mayo-Martin, MB, Lee, Jae Wook, Schultz, PG, Waldmann, H., Chang, Young-Tae, Eisele, F., Burdett, M, Suh, Pann-Ghill, CHANG, YOUNG TAE, Meijer, L, Deuerling, Elke, Bae, YS, Ludolph, B., Gibson, JS, Mayer, Matthias P., Moon, HS, Lee, JW, Choi, KY   +34 more
core   +1 more source

Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression.

PLoS ONE, 2020
The TCIRG1 gene encodes the a3 isoform of vacuolar H+-ATPase (V-ATPase), which forms a proton transport channel in osteoclasts. Defects in this gene lead to functional impairment of osteoclasts and increased bone mass; however, the molecular mechanisms ...
Dongyan Zhang, Liying Lin, Bingwu Yang, Zhen Meng, Bin Zhang   +4 more
doaj   +1 more source

Mechanisms underlying gastric antral slow waves – a human perspective

The Journal of Physiology, EarlyView.
Dirk F. van Helden
wiley   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source