The FEBS Journal, Volume 293, Issue 18, Page 5585-5599, September 2026.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity. [PDF]
Explor Target Antitumor Ther, 2022 Shapovalov G +9 more
europepmc +1 more source
Regulation of inositol 1,4,5-trisphosphate receptor expression [PDF]
, 1999 This thesis describes the regulation of the inositol 1,4,5-triphosphate receptor (InsP3R). The mechanisms of InsP3R regulation were investigated after cloning of the promoters of the human and rat InsP3R-1 gene and visualization of subcellular ...
Deelman, Leo Edwin
core +20 more sources
Jaw1 accelerates the reaction speed of the Ca2+ signals via ITPRs upon GPCR stimulation
Scientific ReportsJaw1/LRMP/IRAG2 enhances Ca2+ release via interaction with inositol 1,4,5-trisphosphate receptors (ITPRs), Ca2+ channels on the endoplasmic reticulum, upon G protein-coupled receptor stimulation. While our previous works demonstrated the increases in the
Takuma Kozono +4 more
doaj +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
Inositol 1,4,5-trisphosphate receptor - reactive oxygen signaling domain regulates excitation-contraction coupling in atrial myocytes. [PDF]
J Mol Cell Cardiol, 2022 Varma D +4 more
europepmc +1 more source
The characterisation of Plc1 : a phospholipase C enzyme identified in the fission yeast Schizosaccharomyces pombe [PDF]
The plc1 gene product (Plc1) of the fission yeast Schizosaccharomycespombe (Sz. pombe) encodes a phosphoinositide-specific phospholipase C (PLC) and most closely resembles the δ class of the PLC isozymes.
Brind, Robert Ian
core
Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP3 (IRBIT). [PDF]
Learn Mem, 2022 Goto JI +4 more
europepmc +1 more source
Studies on ion movements in Malpighian tubules of Locusta migratoria L., with particular reference to their endocrine control [PDF]
, 1990 Intracellular microelectrodes were used in conjunction with ion substitution, agonists and inhibitors of known transport processes and diuretic hormone (DH), to investigate the mechanisms whereby ions cross the basal and apical cell membranes of the ...
Fogg, Kay Elizabeth, Fogg, K.E
core
Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus
Nature CommunicationsMemory persistence, the ability to retain information over time, is a fundamental feature of long-term memory. Although astrocytes contribute to synaptic plasticity, the molecular mechanisms by which they support memory persistence remain unclear.
Hayoung Kim +12 more
doaj +1 more source