Results 201 to 210 of about 1,279,181 (240)

Pharmacological modulators of the inositol 1,4,5-trisphosphate receptor

Neuropharmacology, 1995
Elevation of cytosolic calcium concentrations, induced by many neurotransmitters, plays a crucial role in neuronal function. Some neurotransmitters produce the second messenger InsP3 which activates an intracellular calcium channel (InsP3 receptor) usually located in the endoplasmic reticulum.
F, Michelangeli, M, Mezna, S, Tovey, L G, Sayers   +3 more
openaire   +2 more sources

The inositol 1,4,5-trisphosphate receptors

Cell Calcium, 2005
The inositol (1,4,5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms-InsP3R type 1 (InsP3R1), InsP3R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals.
openaire   +2 more sources

Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms

Journal of Molecular and Cellular Cardiology, 2012
Intracellular Ca(2+) plays an important role in the control of the heart rate through the interaction between Ca(2+) release by ryanodine receptors in the sarcoplasmic reticulum (SR) and the extrusion of Ca(2+) by the sodium-calcium exchanger which generates an inward current. A second type of SR Ca(2+) release channel, the inositol 1,4,5-trisphosphate
Ju, Yue-Kun, Woodcock, Elizabeth, Allen, David, Cannell, Mark B   +3 more
openaire   +3 more sources

Molecular properties of inositol 1,4,5-trisphosphate receptors

Cell Calcium, 1999
The receptors for the second messenger inositol 1,4,5-trisphosphate (IP3) constitute a family of Ca2+ channels responsible for the mobilization of intracellular Ca2+ stores. Three different gene products (types I-III) have been isolated, encoding polypeptides which assemble as large tetrameric structures.
S, Patel, S K, Joseph, A P, Thomas
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Calcium regulation of inositol 1,4,5-trisphosphate receptors

Cell Calcium, 2005
Ca2+ exerts both a stimulatory and inhibitory effect on type-I IP3R channel activity. However, the structural determinants of Ca2+ sensing in IP3Rs are not fully understood. Previous studies by others have identified eight domains of the type-I IP3R that bind 45Ca2+ when expressed as GST-fusion proteins.
Suresh K, Joseph, Samuel, Brownell, M Tariq, Khan   +2 more
openaire   +2 more sources

Inositol 1,4,5-Trisphosphate Receptors and Calcium Signaling

Critical Reviews™ in Neurobiology, 1996
Many cellular responses to extracellular stimuli are mediated by the second messenger inositol 1,4,5-trisphosphate (InsP3). InsP3 releases Ca2+ from intracellular stores by binding to an InsP3 receptor (InSP3R), which is an InsP3-gated Ca2+ release channel.
T, Michikawa, A, Miyawaki, T, Furuichi, K, Mikoshiba   +3 more
openaire   +2 more sources

Distribution of inositol 1,4,5-trisphosphate receptor mRNA in mouse tissues [PDF]

FEBS Letters, 1990
Northern blot analysis demonstrated that the concentration of inositol 1,4,5-trisphosphate (IP3) receptor mRNA was greatest in cerebellar tissue. Moderate amounts of IP3 mRNA were present in brain tissue without cerebellum and tissue of the thymus, heart,
Katsuhiko Mikoshiba, Teiichi Furuichi
exaly   +2 more sources

Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators

Annual Review of Biochemistry, 2004
▪ Abstract  The inositol 1,4,5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ release via IP3Rs is achieved by the ability of IP3R to integrate signals from numerous small molecules and proteins including nucleotides, kinases, and phosphatases, as well
Randen L, Patterson, Darren, Boehning, Solomon H, Snyder   +2 more
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Inositol 1,4,5-trisphosphate receptors: Labeling the inositol 1,4,5-trisphosphate binding site with photoaffinity ligands

Biochemistry, 1993
We have photolabeled the inositol 1,4,5-trisphosphate (IP3) receptor and probed the IP3 ligand binding site using two novel photoaffinity ligands, [125I] (azidosalicyl)aminopropyl-IP3 ([125I]ASA-IP3) and [3H] (benzoyldihydrocinnamyl)aminopropyl-IP3 ([3H]BZDC-IP3).
R J, Mourey, V A, Estevez, J F, Marecek, R K, Barrow, G D, Prestwich, S H, Snyder   +5 more
openaire   +2 more sources

The inositol 1,4,5-trisphosphate receptor.

Ciba Foundation symposium, 1992
Inositol 1,4,5-trisphosphate (InsP3) is a second messenger that releases Ca2+ from its intracellular stores. The InsP3 receptor has been purified and its cDNA has been cloned. We have found that the InsP3 receptor is identical to P400 protein, first identified as a protein enriched in cerebellar Purkinje cells.
K, Mikoshiba, T, Furuichi, A, Miyawaki, S, Yoshikawa, N, Maeda, M, Niinobe, S, Nakade, T, Nakagawa, H, Okano, J, Aruga   +9 more
openaire   +1 more source