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マウス ノウナイ ニオケル イノシトール 1,3,4,5 ヨンリンサン ケツゴウ タンパクシツ ノ セイセイ ト セイカガクテキ カイセキ [PDF]
Yamaguchi, Yoshihide +2 more
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Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium
Nature, 1990Although myo-inositol hexakisphosphate (InsP6; phytate) is the most abundant inositol phosphate in nature and probably has a wide variety of functions, neither the route of its synthesis from myo-inositol nor its metabolic relationships with other inositol-containing compounds (such as the second messenger inositol 1,4,5-trisphosphate, Ins(1,4,5)P3 ...
L R, Stephens, R F, Irvine
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Inositol hexakisphosphate inhibits mineralization of MC3T3-E1 osteoblast cultures
Bone, 2010Inositol hexakisphosphate (IP6, phytic acid) is an endogenous compound present in mammalian cells and tissues. Differentially phosphorylated forms of inositol are well-documented to have important roles in signal transduction, cell proliferation and differentiation, and IP6 in particular has been suggested to inhibit soft tissue calcification ...
William N, Addison, Marc D, McKee
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Inositol hexakisphosphate kinases promote autophagy
The International Journal of Biochemistry & Cell Biology, 2010We and other authors have previously reported that increasing cellular diphosphoinositol pentakisphosphate (InsP(7)) levels increases cell sensitivity to cell death. In the present study, we elucidated the relationship between inositol hexakisphosphate kinases (InsP(6)Ks), which form InsP(7), and autophagy using InsP(6)Ks overexpression and disruption ...
Eiichiro, Nagata +8 more
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myo-Inositol-1,2,3,4,5,6-hexakisphosphate
Phytochemistry, 2003myo-Inositol-1,2,3,4,5,6-hexakisphosphate (Ins P(6)) was first described as an abundant form of phosphorus in plant seeds and other plant tissues and dubbed "phytic acid". Subsequently it was found to be a common constituent in eukaryotic cells, its metabolism a basic component of cellular housekeeping.
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The signaling role of inositol hexakisphosphate kinases (IP6Ks)
Advances in Enzyme Regulation, 2011The past ten years have seen a contained explosion of interest in inositol pyrophosphates. The early cloning of the IP6Ks and the more recent identification of the PP-IP5Ks have allowed the development of essential experimental tools to investigate the physiological role of inositol pyrophosphates.
Cristina, Azevedo +2 more
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Membrane-associated inositol hexakisphosphate binding in bovine retina
Current Eye Research, 1995We investigated the InsP6 binding proteins in bovine retinal membranes and rod outer segments (ROS) by radioligand binding assay and western blotting. The relative affinity of InsP6 for the binding protein was determined by competitive binding of [3H]-InsP6 with increasing concentrations of the unlabeled InsP6 or other isomers. InsP6 specifically binds
N S, Day, A J, Ghalayini, R E, Anderson
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Multitarget Activities of Inositol and Inositol Hexakisphosphate
2020Multiple health beneficial effects have been shown for inositol hexakisphosphate (IP6) and its parent compound myo-inositol (Ins) in animal and human studies. However, the most striking is their consistent and reproducible anticancer effect, actively investigated and demonstrated in various experimental models during the last decades.
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A Femtomole-Sensitivity Mass Assay for Inositol Hexakisphosphate
2010Inositol hexakisphosphate (InsP(6)) is an important component of cells, and its mass levels are usually assayed by either (a) equilibrium labelling of cell cultures with radiolabelled inositol or (b) by a variety of mass assays of differing sensitivities and ambiguities. Here, we describe a mass assay for InsP(6) that is based on phosphorylating InsP(6)
Andrew J, Letcher +2 more
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