Results 141 to 150 of about 11,589 (250)

Epigenetic control of cell identities from epiblast to gastrulation

The FEBS Journal, EarlyView.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

The FEBS Journal, EarlyView.
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S‐WM48, that could inhibit both plasmepsin V and plasmepsin X but plasmepsin IX was not significantly inhibited.
Anthony N. Hodder, Brad E. Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Kate Jarman, Stephen Scally, Peter Czabotar, Hongwu Wang, John A. McCauley, David B. Olsen, Alan F. Cowman   +11 more
wiley   +1 more source

Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling with ¹⁸O-Water. [PDF]

J Am Chem Soc
Kim GD, Liu G, Qiu D, De Leo MG, Gopaldass N, Hermes J, Timmer J, Saiardi A, Mayer A, Jessen HJ.   +9 more
europepmc   +1 more source

Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model

The FEBS Journal, EarlyView.
Stbd1 is an N‐myristoylated, ER‐resident, glycogen‐binding protein whose loss‐of‐function has been associated with insulin resistance. We report that AML12 hepatocytes overexpressing either N‐myristoylated Stbd1 or a non‐N‐myristoylated variant display enhanced AMPK signaling and improved insulin sensitivity, independently of differences in glycogen ...
Andria Theodoulou, Thilo Speckmann, Louiza Potamiti, Otto Baba, Tsuyoshi Morita, Anthi Drousiotou, Mihalis I. Panayiotidis, Annette Schürmann, Petros P. Petrou   +8 more
wiley   +1 more source

Inositol phosphates dynamically enhance stability, solubility, and catalytic activity of mTOR. [PDF]

J Biol Chem
Rameh LE, York JD, Blind RD.
europepmc   +1 more source

The effects of caffeine and adenosine on the microbiome and lipidome of the scalp

International Journal of Cosmetic Science, EarlyView.
At 12 weeks, anti‐hair loss effects were evident with decreased Pseudomonas, Escherichia‐Shigella and Malassezia and increased Talaromyces and Cutibacterium. Lipid levels were impacted, correlating with Escherichia‐Shigella and Talaromyces. Abstract Hair loss is a complex multifactorial process.
Fengzhu Li, Shulin Liu, Zhaoying Han, Yingtian Li, Haowei Chen, Qingying Shi, Jie Tan, Xihong He, Xinyan Liu, Huabing Zhao, Fang Wang   +10 more
wiley   +1 more source

ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism. [PDF]

Proc Natl Acad Sci U S A, 2019
Desfougères Y, Wilson MSC, Laha D, Miller GJ, Saiardi A.   +4 more
europepmc   +1 more source

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

Immunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source

Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug‐Specific Activation Responses In Vitro

Clinical &Experimental Allergy, EarlyView.
Paola Leonor Quan, Laia Ollé, Marina Sabaté‐Bresco, Elizabeth Guruceaga, José Julio Laguna, Inmaculada Doña, Rosa Muñoz‐Cano, José Luis Perez‐Gracia, Margarita Martín, Gabriel Gastaminza   +9 more
wiley   +1 more source

More than flowering: CONSTANS plays multifaceted roles in plant development and stress responses

Journal of Integrative Plant Biology, Volume 67, Issue 3, Page 425-439, March 2025.
This review traces research on CONSTANS (CO), from its discovery and functional studies to the exploration of its mechanisms in regulating flowering time and the circadian clock, and newly discovered functions, providing insight into the roles of CO and laying a foundation for future research.
Bin Yu, Yilong Hu, Xingliang Hou
wiley   +1 more source