Results 161 to 170 of about 86,215 (260)

XPR1 mediates the pancreatic B-cell phosphate flush [PDF]

, 2020
Glucose-stimulated insulin secretion is the hallmark of the pancreatic β-cell, a critical player in the regulation of blood glucose concentration.
Berggren, Bukowiecki, Carpinelli, Christopher J. Barker, Elisabetta Darè, Fernando Henrique Galvão Tessaro, Freinkel, Joilson O. Martins, Martin Köhler, Minami, Per-Olof Berggren, Pierce, Pimentel, Rafael Simas, Rajasekaran, Sabrina de Souza Ferreira, Subu Surendran Rajasekaran, Thais S. Ayala   +17 more
core   +1 more source

Calcium‐dependent antimicrobials: Nature‐inspired materials and designs

Exploration, Volume 4, Issue 5, October 2024.
The paper summarizes calcium's merits in coordination, hydration, ionization, and stereochemistry for acting as a structural former or trigger in biological systems, illuminates its natural roles in pathogens and the immune systems, and discusses its applications in infection medications.
Zhong Wang, Yongjie Zeng, Zubair Ahmed, Hui Qin, Ijaz Ahmad Bhatti, Huiliang Cao   +5 more
wiley   +1 more source

Updated aspects of alpha‐Solanine as a potential anticancer agent: Mechanistic insights and future directions

Food Science &Nutrition, Volume 12, Issue 10, Page 7088-7107, October 2024.
α‐Solanine, extracted from vegetables has a role as an anticancer compound. Illustrated are its molecular structure and experimental evidence of anticancer action in cancer cell lines and animal models, demonstrating increased apoptosis, cell cycle arrest, metastasis reduction and angiogenesis inhibition.
Sudeshna Nandi, Rimpa Sikder, Anish Nag, Somanjana Khatua, Surjit Sen, Nilanjan Chakraborty, Arghya Naskar, Kairat Zhakipbekov, Krishnendu Acharya, Solomon Habtemariam, Dilek Arslan Ateşşahin, Tamar Goloshvili, Afaf Ahmed Aldahish, Javad Sharifi‐Rad, Daniela Calina   +14 more
wiley   +1 more source

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast

Cell, 2023
Ning Qin, Lingyun Li, Xu Ji, Rui Pereira, Yu Chen, Shile Yin, Chaokun Li, Xiaozhen Wan, Danye Qiu, Junfeng Jiang, Hao Luo, Yueping Zhang, Genlai Dong, Yiming Zhang, S. Shi, H. Jessen, Jianye Xia, Yun Chen, C. Larsson, T. Tan, Zihe Liu, Jens Nielsen   +21 more
semanticscholar   +1 more source

Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability

Molecular Brain
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen, Weiwei Cheng   +5 more
doaj   +1 more source

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues. [PDF]

Chem Sci, 2023
Qiu D, Gu C, Liu G, Ritter K, Eisenbeis VB, Bittner T, Gruzdev A, Seidel L, Bengsch B, Shears SB, Jessen HJ.   +10 more
europepmc   +1 more source

NMR spectroscopy studies to elucidate the role of SPX domains in phosphate homeostasis [PDF]

, 2021
This PhD thesis focuses on two main areas of research. The first area deals with structural and functional studies of SPX domains in yeast and plants that are key to the understanding of the basis of eukaryotic phosphate (Pi) homeostasis.
Pipercevic, Joka
core  

Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in Saccharomyces cerevisiae

Biomolecules
The inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Ileana Cornelia Farcasanu   +2 more
doaj   +1 more source

Arabidopsis ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity [PDF]

, 2019
Diphospho-myo-inositol polyphosphates, also termed inositol pyrophosphates, are molecular messengers containing at least one high-energy phosphoanhydride bond and regulate a wide range of cellular processes in eukaryotes.
Fernandez-Rebollo, N, Giehl, RFH, Hofer, A, Jessen, HJ, Laha, D, Parvin, N, Saiardi, A, Schaaf, G, von Wirén, N   +8 more
core  

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

eLife, 2019
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Jinsheng Zhu, Kelvin Lau, Robert Puschmann, Robert K Harmel, Youjun Zhang, Verena Pries, Philipp Gaugler, Larissa Broger, Amit K Dutta, Henning J Jessen, Gabriel Schaaf, Alisdair R Fernie, Ludwig A Hothorn, Dorothea Fiedler, Michael Hothorn   +14 more
doaj   +1 more source