Inotodiol From Inonotus obliquus Chaga Mushroom Induces Atypical Maturation in Dendritic Cells [PDF]
Frontiers in Immunology, 2021 Dendritic cells (DCs) have the ability to stimulate naïve T cells that coordinate subsequent adaptive response toward an inflammatory response or tolerance depending on the DC differentiation level.
Perry Ayn Mayson A. Maza +15 more
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Preventive effects of inotodiol on polyinosinic–polycytidylic acid-induced inflammation in human dermal fibroblasts [PDF]
Heliyon, 2023 Double-strand RNA(dsRNA), which can induce inflammation, can be generated by necrotic keratinocytes in the skin environment. As an analog of dsRNA, polyinosinic–polycytidylic acid (poly(I:C)) is used to induce inflammation via the Toll-like Receptor 3 ...
Gun-Woo Won +6 more
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Isolation, Physicochemical Characterization, and Biological Properties of Inotodiol, the Potent Pharmaceutical Oxysterol from Chaga Mushroom [PDF]
Antioxidants, 2023 Inotodiol, an oxysterol found only in Chaga mushroom, has received attention from the pharmaceutical industry due to its strong antioxidant and anti-allergic activities.
Phu Cuong Nguyen +11 more
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Evaluation of Toxicity and Efficacy of Inotodiol as an Anti-Inflammatory Agent Using Animal Model [PDF]
Molecules, 2022 Chaga mushroom (Inonotus obliquus) comprises polyphenolic compounds, triterpenoids, polysaccharides, and sterols. Among the triterpenoid components, inotodiol has been broadly examined because of its various biological activities.
Thi Minh Nguyet Nguyen +11 more
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Supercritical CO2 Extraction of Triterpenoids from Chaga Sterile Conk of Inonotus obliquus [PDF]
Molecules, 2022 Triterpenoids are among the bioactive components of Chaga, the sterile conk of the medicinal fungus Inonotus obliquus. Supercritical fluid extraction of Chaga triterpenoids was carried out with supercritical CO2, while a modified Folch method was used as
Nghia Huynh +4 more
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Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway. [PDF]
PLoS ONEHepatocellular carcinoma(HCC) has a high mortality and morbidity rate and seriously jeopardizes human life. Chemicals and chemotherapeutic agents have been experiencing problems such as side effects and drug resistance in the treatment of HCC, which ...
Yushuang Xing +13 more
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A Novel Bioanalytical Method for Determination of Inotodiol Isolated from Inonotus Obliquus and Its Application to Pharmacokinetic Study [PDF]
Plants, 2021 In this study, we developed a bioanalytical method using liquid chromatography coupled to triple quadrupole tandem mass spectrometry (LC-MS/MS) to apply to a pharmacokinetic study of inotodiol, which is known for its anti-cancer activity.
Jin Hyeok Kim +5 more
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Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer [PDF]
BiomoleculesInonotus obliquus (Chaga) is a medicinal mushroom with several pharmacological properties that is used as a tea in traditional Chinese medicine. In this study, Chaga water extract was digested in vitro to mimic the natural processing and absorption of ...
Junbiao Wang +13 more
doaj +6 more sources
Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review [PDF]
Current Research in Toxicology, 2023 Cancer has become the second leading cause of death in the world. Integrative cancer therapy management is continuously evolving to enhance treatment outcomes.
Selina Plehn +2 more
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Comparative Analyses of Bioactive Compounds in Inonotus obliquus Conks Growing on Alnus and Betula [PDF]
Biomolecules, 2022 Inonotus obliquus grows in the Northern Hemisphere on some living broadleaved tree species as a pathogen, causing stem rot. In Estonia, the fungus is well known in the Betula species but can also be found on Alnus. Sterile conks of I.
Rein Drenkhan +7 more
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