Results 41 to 50 of about 126,027 (266)

Adaptive neural dynamic surface sliding mode control for uncertain nonlinear systems with unknown input saturation

International Journal of Advanced Robotic Systems, 2016
In this article, an adaptive neural dynamic surface sliding mode control scheme is proposed for uncertain nonlinear systems with unknown input saturation.
Qiang Chen, Linlin Shi, Yurong Nan, Xuemei Ren   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Finite-Time Backstepping Control for Quadrotors With Disturbances and Input Constraints

IEEE Access, 2018
This paper proposes a novel finite-time backstepping framework combined with an auxiliary input-saturation compensator and applies it to tackle the trajectory tracking problem of quadrotors with disturbances and input constraints. Finite-time convergence
Tao Jiang, Defu Lin, Tao Song
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Nonlinear Backstepping Tracking Control for a Vehicular Electronic Throttle With Input Saturation and External Disturbance

IEEE Access, 2018
To achieve more precise positioning of the electronic throttle plate, a nonlinear backstepping tracking control strategy is presented in this paper. In contrast to the existing control schemes for electronic throttles, the input saturation and unknown ...
Bai Rui, Yu Yang, Wang Wei
doaj   +1 more source

Design and Input Allocation for Robots with Saturated Inputs via Genetic Algorithms

IFAC-PapersOnLine, 2018
In this paper we consider fully-actuated and redundantly-actuated robots, whose saturated inputs can have high bandwidth or can be slowly varying (with dynamics). The slowly varying inputs can be considered as configurations for the system. The proposed strategy allows to find the optimal actuators' configuration to optimize a cost function as the ...
Michele Furci, Davide Bicego, Antonio Franchi   +2 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Robust Path-Following Control for AUV under Multiple Uncertainties and Input Saturation

Drones, 2023
In this paper, a robust path-following control strategy is proposed to deal with the path-following problem of the underactuated autonomous underwater vehicle (AUV) with multiple uncertainties and input saturation, and the effectiveness of the proposed ...
Jianming Miao, Xingyu Sun, Qichao Chen, Haosu Zhang, Wenchao Liu, Yanyun Wang   +5 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source