Results 91 to 100 of about 4,073,023 (348)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Project Based Learning and Invitations: A Comparison

Journal of Curriculum Theorizing, 2015
Thispaper compares two instructional approaches: project based learning andinvitations. It begins with a discussion of the definitions of project basedlearning and invitations as well as their theoretical bases.
Cheu-jey Lee
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Assessing the Pedagogical Change by Graduate Teaching Assistants New to Inquiry-based Learning [PDF]

, 2018
There is a great difficulty in how graduate students acclimate to both their student and teaching requirements. Adding to that difficulty, some students are also curious about varying pedagogical techniques.
Ellis, Angie
core  

Teaching Strategies to Encourage Children's Self Direction in the Inquiry-Based Learning Science Curricula of Elementary Schools

, 2020
This study investigates whether inquiry-based learning should be implemented in the Government Guidelines for Teaching (2017) for elementary school learners in science classes.
OMAE, Akimasa, 大前, 暁政, オオマエ, アキマサ   +2 more
core   +1 more source

Design for Inquiry-based Learning Case Studies

Journal of Learning Development in Higher Education, 2009
The past six months have witnessed the development and dissemination of a number of case studies of inquiry-based learning (IBL) projects supported and developed by the Centre for Inquiry-based Learning in the Arts and Social Sciences (CILASS), a Centre ...
Jamie Peter Wood
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The Role of Learning Models in Enhancing Scientific Literacy: A Critical Review Evaluation

Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram
This literature review examines the impact of learning models on students' scientific literacy and provides critiques of the strengths and weaknesses of the literature. These critiques offer recommendations for future research.
Winata Tegar Saputra, Diana Rochintaniawati, Rika Rafikah Agustin   +2 more
doaj   +1 more source

Training of Development of Inquiry-Based and Project-Based Chemistry Learning Design for Chemistry & Science Teachers

J-PEK (Jurnal Pembelajaran Kimia), 2023
Abstrak – Nowadays, the demands of curriculum are increasing in achieving better standards of learning process. The low ability of chemistry and science teachers in developing inquiry-based and project-based learning designs is a problem that must be ...
Oktavia Sulistina, Hayuni Retno Widarti, Habiddin Habiddin, Herunata Herunata, Yahmin Yahmin, Samudra Mutiara Hasanah, Dhea Fairuza Zahirah   +6 more
doaj