Results 81 to 90 of about 2,669,449 (259)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Training of Development of Inquiry-Based and Project-Based Chemistry Learning Design for Chemistry & Science Teachers

J-PEK (Jurnal Pembelajaran Kimia), 2023
Abstrak – Nowadays, the demands of curriculum are increasing in achieving better standards of learning process. The low ability of chemistry and science teachers in developing inquiry-based and project-based learning designs is a problem that must be ...
Oktavia Sulistina, Hayuni Retno Widarti, Habiddin Habiddin, Herunata Herunata, Yahmin Yahmin, Samudra Mutiara Hasanah, Dhea Fairuza Zahirah   +6 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

THE EFFECTIVENESS COMPARISON BETWEEN INQUIRY AND PROBLEM BASED LEARNING TOWARDS GEOGRAPHY LEARNING OUTCOMES

Geosfera Indonesia, 2019
This study aims to determine the differences of learning outcomes between students that were performed using inquiry and student who were applied using problem based learning in classes of X SMA 2 Plakat Tinggi.
Upang Septa Putra, Muhsinatun Siasah Masruri   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Inquiry Based Learning and Its Effectiveness

International Journal of Assessment Tools in Education, 2016
The aim of this study is to investigate the effectiveness of the inquiry based learning on the skills of the prospective teachers for the laboratory applications I course activities related to the developed chemistry experiments using semi-experimental ...
Sevilay Karamustafaoğlu, Ayşegül Celep Havuz   +1 more
doaj   +1 more source

Hypothetical learning trajectory in microbiology course through argumentation-based inquiry learning

JPBI (Jurnal Pendidikan Biologi Indonesia)
The application of effective teaching methods needs to be implemented to improve the quality of microbiology education which can empower important competencies in the current era.
Evi Roviati, Ria Yulia Gloria, Rizki Sukma Wijaya   +2 more
doaj   +1 more source