Results 131 to 140 of about 1,027,608 (297)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Effects of just-in-time inquiry prompts and principle-based self-explanation guidance on learning and use of domain texts in simulation-based inquiry learning

Frontiers in Education
Although scientific inquiry with simulations may enhance learning, learners often face challenges creating high demand for self-regulation due to an abundance of information in simulations and supplementary instructional texts.
Mari Fukuda, Mari Fukuda, John C. Nesbit, Philip H. Winne   +3 more
doaj   +1 more source

Computer-assisted instruction versus inquiry-based learning: The importance of working memory capacity. [PDF]

PLoS One, 2021
Chevalère J, Cazenave L, Berthon M, Martinez R, Mazenod V, Borion MC, Pailler D, Rocher N, Cadet R, Lenne C, Maïonchi-Pino N, Huguet P.   +11 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Inquiry based learning

Вестник Пермского государственного гуманитарно-педагогического университета. Серия № 1. Психологические и педагогические науки, 2014
Статья анализирует три подхода к обучению языкам (модели применимы к другим дисциплинам). Первый подход знаниево-ориентированный предполагает заучивание лексики и репродуцирование материала, трансляцию материала в фактическом виде, предъявление в готовом виде синтаксических конструкций и грамматических правил, их отработку в упражнениях, оценивание ...
openaire   +1 more source

LILAC 2009 conference report [PDF]

, 2009
The fifth annual Librarians Information Literacy Annual Conference (LILAC) took place at Cardiff University from 30 March to 1 April 2009. Around 300 delegates gathered together to hear from four keynote speakers, and to attend a wide choice of ...
Patterson, Ruth
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Open Inquiry based learning experiences to understand the Nature of Science [PDF]

, 2014
In this paper we address the question of the efficacy of an inquiry-based learning approach, with different levels of teacher’s guidance, to introduce the students to fundamental aspects of the Nature of Science (NoS). Explicit pedagogical approaches, in
FAZIO, Claudio, MINEO, Rosa Maria, PERSANO ADORNO, Dominique, PIZZOLATO, Nicola   +3 more
core  

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Exploring the impact of web-based inquiry on elementary school students’ science identity development in a STEM learning unit

Humanities & Social Sciences Communications
One of the primary objectives of science education is to cultivate students’ science identity, and evidence points to the efficacy of inquiry-based learning in advancing this objective.
Lu Huang, Xinning Pei
doaj   +1 more source