Results 51 to 60 of about 67,174 (263)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

DojoIBL: Online Inquiry-Based Learning [PDF]

, 2017
DojoIBL is a web based platform to support collaborative inquiry-based learning processes. It imitates real-world research processes and organizes inquiry activities into several phases. DojoIBL considers lessons learned from the weSPOT project and offers a cloud-based highly scalable infrastructure that has a strong focus on (mobile) data collection ...
Suarez, Angel, Ternier, Stefaan, Specht, Marcus   +2 more
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Development of Humanistic Statistics Learning Devices Based one Inquiry and Mind Mapping Models

Al-Jabar, 2018
The purpose of this research are: (1) to determine the characteristic of humanistic statistics learning, (2) to obtain a humanistic statistics learning tools based on valid, practical, and effective inquiry and mind mapping learning model.
Santika Lya Diah Pramesti, Salafudin Salafudin   +1 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

THE EFFECTIVENESS OF INQUIRY BASED LEARNING FOR NATURAL SCIENCE LEARNING IN ELEMENTARY SCHOOL

Journal of Education Technology, 2017
This paper primarily emphasized on describing the use of inquiry in natural science learning at primary school. This study also exposed the validity of inquiry strategy in natural science learning to improve primary schools students’ comprehension ...
Dek Ngurah Laba Laksana
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Effect of Open Learning Achievement in Studying Physics Inquiry from the Scientific Working of Students in SMAN 1 Blitar

Jurnal Pendidikan Sains, 2014
Pengaruh Pembelajaran Open Inquiry terhadap Prestasi Belajar Fisika Ditinjau dari Kerja Ilmiah Siswa SMA Negeri 1 Blitar Abstract:  Learning physics are still teacher-centered learning. Students tend to be passive in following the teaching of physics.
Ratnaningtyas Martuti
doaj   +1 more source

META-ANALISIS PENGARUH PENERAPAN MODEL PEMBELAJARAN INKUIRI DALAM HASIL BELAJAR FISIKA SISWA

Jambura Physics Journal, 2020
This research is a meta-analytic study that uses qualitative analysis methods with documentation data collection techniques with pusposive sampling techniques. In 10 journal articles analyzed that the results of 10 research journal articles show that the
Irpan Irpan, Yoga Budi Bhakti
doaj   +1 more source